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Multi temperal single-cell profiling decodes cross-talk of γδ17 T cells and neutrophils in radiation pneumonitis

GSE236049 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/05/24 Platform GPL28330
Summary
Radiation pneumonitis (RP) is a common and fatal complication in thoracic radiation therapy. The immune microenvironment plays an important role in the RP development. However, the full scope of radiation immune changes over time remains unclear. In this study, a murine model of RP was established, and distinct early (10 days) and late phases (100 days) were defined. We conducted single-cell RNA sequencing and related RNA-seq and proteomics to explore the underlying mechanisms of persistent inflammation during RP. By examining the immunological effects of RP over time at the single-cell level, we shed light on its dynamic immunological effects of RP over time at single-cell resolution and provided potential therapeutic targets for clinical interventions.
Published in
Multitemporal single-cell profiling decoding crosstalk between γδ17 T cells and neutrophils in radiation pneumonitis
Ren W, Zhou X, Jiang Z et al. · Clinical and translational medicine 2024 · PMID 38760891 · doi:10.1002/ctm2.1700
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Also filed as BioProject PRJNA988499 and SRA study SRP446330. Searching any of these in the dataset finder brings you back here.

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