Aspartate signaling increases the aggressiveness of lung metastases by inducing eIF5A-mediated translation
RNA-seq (gene expression) · mouse · 51 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 51 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Aspartate signalling drives lung metastasis via alternative translationNature · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE236087_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA988804 and SRA study SRP446354. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 51 more — browse all 51 samples with per-sample file links →
- GSE273079 Castration Increases Aggressiveness of Prostatic Luminal Progenitor Cells in Prostate Cancer Through FosL1/AP-1-Mediated Transcriptional Reprogramming 384 samples shares aggressiveness, increases
- GSE261778 Iron oxide nanoparticles inhibit tumor progression and suppress lung metastases in mouse models of breast cancer [RNA-seq] 49 samples shares metastases, lung
- GSE292205 Transcriptional analysis of cell lines derived from primary mammary tumors and lung micrometastases 45 samples shares metastases, lung
- GSE286275 Insulin Resistance Increases TNBC Aggressiveness and Brain Metastasis via Adipocyte-derived Exosomes 38 samples shares aggressiveness, increases
- GSE276180 Single-cell temporal landscape of tumor microenvironment of lung cancer and lung metastases 37 samples shares metastases, lung
- GSE261780 Iron oxide nanoparticles inhibit tumor progression and suppress lung metastases in mouse models of breast cancer 72 samples shares metastases, lung
- GSE327213 Increased mRNA translation delays tumor initiation and exposes a therapeutic vulnerability in lung cancer 16 samples shares translation, lung
- GSE278570 Neutrophils physically interact with tumor cells to form a signaling niche promoting breast cancer aggressiveness 309 samples shares aggressiveness
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.