Insulin Resistance Increases TNBC Aggressiveness and Brain Metastasis via Adipocyte-derived Exosomes

This dataset includes mRNA sequencing data obtained from 4T1 cells, either from in vitro cell culture, or clonogenic assay from brain, or primary tumor treated with exosomes from insulin sensitive (IS) or induslin resistant (IR) adipocytes; and 4T1 cells cultured in vitro and treated with miR-145a-3p. Exosomal small RNA from IS and IR aidpocytes derived exsomes were also included. RNA was extracted and sequenced to investigate differential gene expression and associated biological pathways. The aim of the study is to elucidate how insulin resistance in adipocytes influences gene expression, cancer aggressiveness and metastasis. Data include raw and processed mRNA sequencing files from replicates for each condition.