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PI3K-Akt signaling regulates Scx-lineage tenocytes and Tppp3-lineage tendon sheath synovial cells in physiological tendon regeneration

GSE236106 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/03/15 Platform GPL16417
Summary
We identify a PI3K-Akt signaling pathway which is specifically upregulated in neonatal murine injured Achilles tendons. PI3K-Akt signaling inhibition in neonatal murine Achilles tendon rupture model decreases cell proliferation and cell migration to the regenerating tendons in both Scx-lineage intrinsic tenocytes and Tppp3-lineage extrinsic tendon sheath synovial cells. Moreover, PI3K-Akt signaling inhibition decreases stemness and promotes mature tenogenic differentiation in both Scx-lineage and Tppp3-lineage cells. Collectively, PI3K-Akt signaling plays an important role in physiological tendon regeneration.
Published in
PI3K-Akt signalling regulates Scx-lineage tenocytes and Tppp3-lineage paratenon sheath cells in neonatal tendon regeneration
Goto A, Komura S, Kato K et al. · Nature communications 2025 · PMID 40254618 · doi:10.1038/s41467-025-59010-y
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Also filed as BioProject PRJNA989042 and SRA study SRP446467. Searching any of these in the dataset finder brings you back here.

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