TLR2 in γδ T cells is required for metabolic support of IL-17A ocular mucosal immune response to a commensal bacterium [RNA-seq]
RNA-seq (gene expression) · mouse · 11 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 11 samples: 3 × RNA-seq_WT mice, naïve, vs 3 × RNA-seq_TLR2-deficient mice, C. mast inoculated, vs 3 × RNA-seq_WT mice, C. mast inoculated, vs 2 × RNA-seq_TLR2-deficient mice, naïve,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- TLR2 Supports γδ T cell IL-17A Response to ocular surface commensals by Metabolic ReprogrammingbioRxiv : the preprint server for biology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE236386_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA990735 and SRA study SRP447139. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 11 samples.
How we read this: 4 replicated groups read from 11 sample titles; they account for 11 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7529010 RNA-seq_TLR2-deficient mice, naïve, rep1 RNA-seq_TLR2-deficient …
- GSM7529011 RNA-seq_TLR2-deficient mice, naïve, rep2 RNA-seq_TLR2-deficient …
- GSM7529012 RNA-seq_WT mice, naïve, rep1 RNA-seq_WT mice, naïve,
- GSM7529013 RNA-seq_WT mice, naïve, rep2 RNA-seq_WT mice, naïve,
- GSM7529014 RNA-seq_WT mice, naïve, rep3 RNA-seq_WT mice, naïve,
- GSM7529015 RNA-seq_TLR2-deficient mice, C. mast inoculated, rep1 RNA-seq_TLR2-deficient …
- GSM7529016 RNA-seq_TLR2-deficient mice, C. mast inoculated, rep2 RNA-seq_TLR2-deficient …
- GSM7529017 RNA-seq_TLR2-deficient mice, C. mast inoculated, rep3 RNA-seq_TLR2-deficient …
- GSM7529018 RNA-seq_WT mice, C. mast inoculated, rep1 RNA-seq_WT mice, C. mas…
- GSM7529019 RNA-seq_WT mice, C. mast inoculated, rep2 RNA-seq_WT mice, C. mas…
- GSM7529020 RNA-seq_WT mice, C. mast inoculated, rep3 RNA-seq_WT mice, C. mas…
- GSE236387 TLR2 in γδ T cells is required for metabolic support of IL-17A ocular mucosal immune response to a commensal bacterium 19 samples shares il-17a, tlr2, commensal, bacterium, required, support, mucosal
- GSE326266 Commensal-derived acetylcholine enhances mucosal immune education [mouse_lamina_propria_bulk_RNA-seq] 16 samples shares commensal, mucosal, rna-seq
- GSE326264 Commensal-derived acetylcholine enhances mucosal immune education [mouse_ileum_lamina_propria_scRNA-seq] 2 samples shares commensal, mucosal, rna-seq
- GSE320380 Competition between commensal protists shapes gut mucosal immunity in mice 59 samples shares commensal, mucosal
- GSE283666 Gut Commensal Parabacteroides goldsteinii mitigates LRRK2 Parkinsonism through reducing neuroinflammation and multifaceted effects on gut homeostasis [RNA-seq] 54 samples shares commensal, rna-seq
- GSE272772 APOE Protects Against Severe Infection with Mycobacterium tuberculosis by Restraining Production of Neutrophil Extracellular Traps (scRNA-Seq) 34 samples shares bacterium, rna-seq
- GSE319538 Rectal RNA-seq of mice treated with a multistrain Lactobacillus/Bifidobacterium-derived postbiotic (IBM) 12 samples shares bacterium, rna-seq
- GSE291007 Phase variation in Mycobacterium bovis frd operon disrupts the succinate/HIF-1α/IL-1β axis to drive immunometabolic rewiring and enhance pathogenicity [RNA-seq] 6 samples shares bacterium, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.