← BioTransfer GEO Dataset Finder
GEO series

Mutations in the splicing factor SF3B1 are linked to frequent emergence of HLA-DRlow/neg monocytes in lower-risk myelodysplastic neoplasms

GSE236535 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2024/04/18 Platform GPL20301
Summary
Recurrent mutations in splicing factors, in particular the splicing factor 3B subunit 1 (SF3B1), are commonly seen in lower-risk (LR) myelodysplastic neoplasms (MDS) and result in various aberrantly spliced transcripts. The cell type-specific changes and their contribution to immune dysregulation in MDS remain vaguely understood. In this study, we performed RNA sequencing on classical monocytes isolated from patients with an isolated SF3B1K700E hotspot mutation. Our analysis revealed downregulated expression of genes involved in inflammatory cytokine signaling, as well as differential mRNA splicing of several genes involved in the regulation of the defense response and cytokine signaling, mRNA metabolism, apoptotic signaling, and mitotic cell cycle.
Published in
Mutations in the splicing factor SF3B1 are linked to frequent emergence of HLA-DR(low/neg) monocytes in lower-risk myelodysplastic neoplasms
Winter S, Schneider M, Oelschlaegel U et al. · Leukemia 2024 · PMID 38632316 · doi:10.1038/s41375-024-02249-z
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE236535_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA991542 and SRA study SRP447446. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 9 more — browse all 9 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.