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Gene expression profile at the single cell level of hematopoietic stem/progenitor cells (HSPCs) derived from iPSC at day 12 of differentiation; and from erythroid cultures derived from HS/PC-iPSC at day 4 (RNA-Seq)

GSE236709 Homo sapiens Expression profiling by high throughput sequencing 5 samples Submitted 2025/05/02 Platform GPL18573
Summary
Myelodisplastic syndromes are a oligoclonal disease starting at the level of the stem/progenitor compartment. We use scRNAseq to determine the transcriptome changes and clonal evolution of MDS low and high risk
Published in
A heterozygous CEBPA mutation disrupting the bZIP domain in a RUNX1 and SRSF2 mutational background causes MDS disease progression
Almaghrabi R, Alyahyawi Y, Keane P et al. · Nature communications 2025 · PMID 40593493 · doi:10.1038/s41467-025-60192-8
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Direct links to NCBI, no account and no request form: the whole study as GSE236709_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 5 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA992213 and SRA study SRP447844. Searching any of these in the dataset finder brings you back here.

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