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Gene expression profiling of MDA-MB-231 cells incubated with therapy induced senescence secretome

GSE236953 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2024/03/25 Platform GPL24676
Summary
TNBC, associated with poor prognosis and high tumour recurrence, are often treated with anti-mitotic drugs. However, cells may bypass treatment-induced cell death via mitotic slippage, resulting in multinucleated polyploid cells and senescence activation. Senescent cancer cells represent a population of residual disease and are highly secretory. The SASP elicited is enriched in soluble cytokines linked to tumor recurrence and distant metastasis. In contrast, sEVs derived from senescent cancer cells represent an underappreciated aspect of SASP and its mechanistic role in mediating paracrine effects remains poorly-understood. Here, we show senescent sEVs as a distinct population of SASP that could elicit anti-tumor activity.
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Also filed as BioProject PRJNA993184 and SRA study SRP448383. Searching any of these in the dataset finder brings you back here.

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