Transcriptomic changes in Grin2b-C456Y-mutant mice with NMDAR activation
RNA-seq (gene expression) · mouse · 23 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 23 samples: 6 × Heterotype-DCS-treated vs 6 × Heterotype-DCS-vehicle vs 6 × Wildtype-DCS-vehicle vs 5 × Wildtype-DCS-treatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE237027_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA993566 and SRA study SRP448494. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 6 samples read as cases, 12 as controls.
How we read this: 4 replicated groups read from 23 sample titles; they account for 23 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7593197 Heterotype-DCS-treated replicate1 Heterotype-DCS-treated
- GSM7593198 Heterotype-DCS-treated replicate2 Heterotype-DCS-treated
- GSM7593199 Heterotype-DCS-treated replicate3 Heterotype-DCS-treated
- GSM7593200 Heterotype-DCS-treated replicate4 Heterotype-DCS-treated
- GSM7593201 Heterotype-DCS-treated replicate5 Heterotype-DCS-treated
- GSM7593202 Heterotype-DCS-treated replicate6 Heterotype-DCS-treated
- GSM7593203 Heterotype-DCS-vehicle replicate1 Heterotype-DCS-vehicle
- GSM7593204 Heterotype-DCS-vehicle replicate2 Heterotype-DCS-vehicle
- GSM7593205 Heterotype-DCS-vehicle replicate3 Heterotype-DCS-vehicle
- GSM7593206 Heterotype-DCS-vehicle replicate4 Heterotype-DCS-vehicle
- GSM7593207 Heterotype-DCS-vehicle replicate5 Heterotype-DCS-vehicle
- GSM7593208 Heterotype-DCS-vehicle replicate6 Heterotype-DCS-vehicle
- GSM7593209 Wildtype-DCS-treated replicate1 Wildtype-DCS-treated
- GSM7593210 Wildtype-DCS-treated replicate2 Wildtype-DCS-treated
- GSM7593211 Wildtype-DCS-treated replicate3 Wildtype-DCS-treated
- GSM7593212 Wildtype-DCS-treated replicate4 Wildtype-DCS-treated
- GSM7593213 Wildtype-DCS-treated replicate5 Wildtype-DCS-treated
- GSM7593214 Wildtype-DCS-vehicle replicate1 Wildtype-DCS-vehicle
- GSM7593215 Wildtype-DCS-vehicle replicate2 Wildtype-DCS-vehicle
- GSM7593216 Wildtype-DCS-vehicle replicate3 Wildtype-DCS-vehicle
- GSM7593217 Wildtype-DCS-vehicle replicate4 Wildtype-DCS-vehicle
- GSM7593218 Wildtype-DCS-vehicle replicate5 Wildtype-DCS-vehicle
- GSM7593219 Wildtype-DCS-vehicle replicate6 Wildtype-DCS-vehicle
- GSE275510 Deciphering Motor Dysfunction and Microglial Activation in mThy1-α-Synuclein Mice: A Comprehensive Study of Behavioral, Gene Experssion, and Methylation Changes [RNA-Seq] 20 samples shares activation, changes
- GSE196745 Changes in Ikaros binding and histone-modifications upon oncogenic β-catenin activation [ChIP-Seq] 30 samples shares activation, changes
- GSE295506 Transcriptomic Expression Profile Changes in Lung Tissue of Asthmatic Mice 11 samples shares changes
- GSE331176 Phagosome-mediated activation of STING by purine and pyrimidine-based bacterial cyclic dinucleotides 380 samples shares activation
- GSE279813 Gene expression changes in skin of dihydrotestosterone-induced mice after treatment of a newly-developed traditional Chinese medicine formula, Hanlianxiang. 24 samples shares changes
- GSE316925 Transcriptome changes in trigeminal ganglia in the mouse chronic constriction injury of the infraorbital nerve model - role of TRPM3. 136 samples shares changes
- GSE243942 Spatio-temporal X-linked gene reactivation in the mouse germline reveals site-specific retention of epigenetic silencing [RNA-seq] 125 samples shares activation
- GSE225651 Brain changes in responses of mice to intracerebral hemorrhage at the acute stages 12 samples shares changes
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.