GEO series
Transcriptomic changes in Grin2b-C456Y-mutant mice with NMDAR activation
GSE237027
Mus musculus
Expression profiling by high throughput sequencing
23 samples
2026/07/09
GPL24247
Summary
Our previous study reported a Grin2b-mutant mouse line carrying a point mutation identified in individuals with ASD (Grin2b+/C456Y mice), which show suppressed long-term depression and anxiolytic-like behavior that are responsive to early chronic D-cycloserine (DCS) treatment (postnatal day 7 to 16) for pharmacological activation of NMDARs. To figure out the rescue mechanism, we attempted RNA-Seq analysis of wild-type (WT) and Grin2b+/C456Y mice that are early and chronically treated with vehicle and DCS.
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