Expression profiling of tumor-infiltrating CD4+ FOXP3- conventional T cells from tumors of wildtype and Foxp3-Cre x CK2b-fl/fl mice
RNA-seq (gene expression) · mouse · 10 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 10 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Polyamines regulate adaptive antitumor immunity by functional specialization of regulatory T cellsImmunity · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE237146_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA994062 and SRA study SRP448840. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 10 more — browse all 10 samples with per-sample file links →
- GSE294977 Transcriptomic profiling of tumor-infiltrating and lymph node-derived Treg and B cells in Foxp3-Cre-YFP and Foxp3-Cre-YFP Appl2f/f melanoma-bearing Mice 24 samples shares foxp3-cre, foxp3, tumor-infiltrating
- GSE310947 Soluble CD137 produced by Foxp3+ regulatory CD4 T cells is immunosuppressive and restrains ongoing autoimmune diabetes 15 samples shares foxp3, cd4
- GSE325329 Transcriptomic profiling of macrophages that phagocytosed apoptotic Treg or conventional CD4⁺ T (Tconv) cells under different polarization conditions [RNA-Seq] 28 samples shares cd4, conventional
- GSE306145 Bulk RNA sequencing of quadricep in wildtype and Foxp3-DTR mice in synthetic material implant fibrosis 10 samples shares foxp3, wildtype
- GSE260791 Correction of age-associated defects in dendritic cell functions enables CD4+T cells to eradicate tumors in the elderly 30 samples shares cd4
- GSE303349 CXCL16-driven CD4+ T cells orchestrate immunosurveillance against MHC-I-deficient tumors 24 samples shares cd4
- GSE275471 Proximity-dependent labeling identifies dendritic cells that prime the antitumor CD4+ T cell response 857 samples shares cd4
- GSE278003 Single cell RNA sequencing of CD45+ immune cells from tumor and tumor-adjacent mammary adipose tissue in a postmenopausal breast cancer model of lean, obese, and weight loss Trem2+/+ and Trem2-/- mice 92 samples shares cd4
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.