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Regulation of mRNA translation by RNH1 in hematopoietic cells

GSE237169 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/03/20 Platform GPL21290
Summary
Ribonuclease Inhibitor (RI also known as Rnh1) is a 50 kDa, ubiquitously expressed leucine-rich repeat (LRR) containing protein. It binds to pancreatic-type ribonucleases and inhibit their function. However, the entire biological role of Rnh1 is unknown. We generated RNH1 knock out K562 cells by CRISPR/Cas9 method. We isolated polysomal RNA from control and RNH1-deficient K562 cells to quantify actively translated mRNAs by RNA-seq.
Published in
Ribonuclease inhibitor and angiogenin system regulates cell type-specific global translation
Stillinovic M, Sarangdhar MA, Andina N et al. · Science advances 2024 · PMID 38820160 · doi:10.1126/sciadv.adl0320
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Also filed as BioProject PRJNA994104 and SRA study SRP448854. Searching any of these in the dataset finder brings you back here.

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