Transcriptional profiling of cortex from a mouse model of Huntington's disease (Q140) crossed with Pms2 heterozygous and homozygous mice [Pms2]
RNA-seq (gene expression) · mouse · 48 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 48 samples: 48 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Distinct mismatch-repair complex genes set neuronal CAG-repeat expansion rate to drive selective pathogenesis in HD miceCell · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE237577_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA995767 and SRA study SRP449937. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 48 sample titles: 48 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7633296 Het (Q140) KI Cortex female mRNA rep1 [Pms2]
- GSM7633298 Het (Q140) KI Cortex female mRNA rep2 [Pms2]
- GSM7633299 Het (Q140) KI Cortex female mRNA rep3 [Pms2]
- GSM7633300 Het (Q140) KI Cortex female mRNA rep4 [Pms2]
- GSM7633301 Het (Q140) KI Cortex male mRNA rep1 [Pms2]
- GSM7633303 Het (Q140) KI Cortex male mRNA rep2 [Pms2]
- GSM7633304 Het (Q140) KI Cortex male mRNA rep3 [Pms2]
- GSM7633305 Het (Q140) KI Cortex male mRNA rep4 [Pms2]
- GSM7633306 Het (Q140) KI X Pms2-/- Cortex female mRNA rep1 [Pms2]
- GSM7633307 Het (Q140) KI X Pms2-/- Cortex female mRNA rep2 [Pms2]
- GSM7633309 Het (Q140) KI X Pms2-/- Cortex female mRNA rep3 [Pms2]
- GSM7633310 Het (Q140) KI X Pms2-/- Cortex female mRNA rep4 [Pms2]
- GSM7633311 Het (Q140) KI X Pms2-/- Cortex male mRNA rep1 [Pms2]
- GSM7633312 Het (Q140) KI X Pms2-/- Cortex male mRNA rep2 [Pms2]
- GSM7633314 Het (Q140) KI X Pms2-/- Cortex male mRNA rep3 [Pms2]
- GSM7633315 Het (Q140) KI X Pms2-/- Cortex male mRNA rep4 [Pms2]
- GSM7633316 Het (Q140) KI X Pms2+/- Cortex female mRNA rep1 [Pms2]
- GSM7633317 Het (Q140) KI X Pms2+/- Cortex female mRNA rep2 [Pms2]
- GSM7633319 Het (Q140) KI X Pms2+/- Cortex female mRNA rep3 [Pms2]
- GSM7633320 Het (Q140) KI X Pms2+/- Cortex female mRNA rep4 [Pms2]
- GSM7633321 Het (Q140) KI X Pms2+/- Cortex male mRNA rep1 [Pms2]
- GSM7633322 Het (Q140) KI X Pms2+/- Cortex male mRNA rep2 [Pms2]
- GSM7633324 Het (Q140) KI X Pms2+/- Cortex male mRNA rep3 [Pms2]
- GSM7633325 Het (Q140) KI X Pms2+/- Cortex male mRNA rep4 [Pms2]
- GSM7633326 Pms2-/- Cortex female mRNA rep1 [Pms2]
- GSM7633327 Pms2-/- Cortex female mRNA rep2 [Pms2]
- GSM7633329 Pms2-/- Cortex female mRNA rep3 [Pms2]
- GSM7633330 Pms2-/- Cortex female mRNA rep4 [Pms2]
- GSM7633331 Pms2-/- Cortex male mRNA rep1 [Pms2]
- GSM7633332 Pms2-/- Cortex male mRNA rep2 [Pms2]
- GSM7633334 Pms2-/- Cortex male mRNA rep3 [Pms2]
- GSM7633335 Pms2-/- Cortex male mRNA rep4 [Pms2]
- GSM7633336 Pms2+/- Cortex female mRNA rep1 [Pms2]
- GSM7633337 Pms2+/- Cortex female mRNA rep2 [Pms2]
- GSM7633339 Pms2+/- Cortex female mRNA rep3 [Pms2]
- GSM7633340 Pms2+/- Cortex female mRNA rep4 [Pms2]
- GSM7633341 Pms2+/- Cortex male mRNA rep1 [Pms2]
- GSM7633342 Pms2+/- Cortex male mRNA rep2 [Pms2]
- GSM7633344 Pms2+/- Cortex male mRNA rep3 [Pms2]
- GSM7633345 Pms2+/- Cortex male mRNA rep4 [Pms2]
+ 8 more — browse all 48 samples with per-sample file links →
- GSE237584 Transcriptional profiling of striatum from a mouse model of Huntington's disease (Q140) crossed with Pms2 heterozygous and homozygous mice [Pms2_striatum] 48 samples shares q140, pms2, heterozygous, huntington, homozygous, crossed
- GSE229815 Transcriptional profiling of 12 month striatum and cortex from a mouse model of Huntington's disease (Q140) crossed with Msh2 heterozygous or homozygous conditional knockout mice [Msh2_12mon] 138 samples shares q140, heterozygous, huntington, homozygous, crossed, cortex
- GSE288739 Transcriptional profiling of striatum and cortex from a mouse model of Huntington's disease (Q140) crossed with Pms1 heterozygous and homozygous mice 96 samples shares q140, heterozygous, huntington, homozygous, crossed, cortex
- GSE271022 Transcriptional profiling of cerebral cortex and striatum from a mouse model of Huntington's disease (Q140) crossed with Msh6 heterozygous and homozygous mice 96 samples shares q140, heterozygous, huntington, homozygous, crossed, cortex
- GSE229826 Transcriptional profiling of cerebral cortex from a mouse model of Huntington's disease (Q140) crossed with Msh3 heterozygous and homozygous mice [Msh3_cortex] 48 samples shares q140, heterozygous, huntington, homozygous, crossed, cortex
- GSE237510 Transcriptional profiling of cortex from a mouse model of Huntington's disease (Q140) crossed with Mlh1 heterozygous and homozygous mice [Mlh1_4m] 48 samples shares q140, heterozygous, huntington, homozygous, crossed, cortex
- GSE237564 Transcriptional profiling of cortex from a mouse model of Huntington's disease (Q140) crossed with Msh3 heterozygous and homozygous mice [Msh3_cortex_6m] 48 samples shares q140, heterozygous, huntington, homozygous, crossed, cortex
- GSE237667 Transcriptional profiling of cortex from a mouse model of Huntington's disease (Q140) crossed with Ccdc82 heterozygous and homozygous mice [Ccdc82] 47 samples shares q140, heterozygous, huntington, homozygous, crossed, cortex
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.