53BP1 loss elicits cGAS-STING-dependent antitumor immunity in ovarian and pancreatic cancer
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 5 × KPC tumor, biol vs 5 × KPC 53BP1 KO tumor, biol vs 3 × ID8 tumor, biol vs 3 × ID8 53BP1 KO tumor, biolGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- 53BP1 loss elicits cGAS-STING-dependent antitumor immunity in ovarian and pancreatic cancerNature communications · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE237615_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA996040 and SRA study SRP450632. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 4 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7634845 ID8 tumor, biol rep 1 ID8 tumor, biol
- GSM7634846 ID8 tumor, biol rep 2 ID8 tumor, biol
- GSM7634847 ID8 tumor, biol rep 3 ID8 tumor, biol
- GSM7634848 ID8 53BP1 KO tumor, biol rep 1 ID8 53BP1 KO tumor, biol
- GSM7634849 ID8 53BP1 KO tumor, biol rep 2 ID8 53BP1 KO tumor, biol
- GSM7634850 ID8 53BP1 KO tumor, biol rep 3 ID8 53BP1 KO tumor, biol
- GSM7634851 KPC tumor, biol rep 1 KPC tumor, biol
- GSM7634852 KPC tumor, biol rep 2 KPC tumor, biol
- GSM7634853 KPC tumor, biol rep 3 KPC tumor, biol
- GSM7634854 KPC tumor, biol rep 4 KPC tumor, biol
- GSM7634855 KPC tumor, biol rep 5 KPC tumor, biol
- GSM7634856 KPC 53BP1 KO tumor, biol rep 1 KPC 53BP1 KO tumor, biol
- GSM7634857 KPC 53BP1 KO tumor, biol rep 2 KPC 53BP1 KO tumor, biol
- GSM7634858 KPC 53BP1 KO tumor, biol rep 3 KPC 53BP1 KO tumor, biol
- GSM7634859 KPC 53BP1 KO tumor, biol rep 4 KPC 53BP1 KO tumor, biol
- GSM7634860 KPC 53BP1 KO tumor, biol rep 5 KPC 53BP1 KO tumor, biol
- GSE324935 IFN-γ and TLR9 signaling reprogram tumor-associated macrophages to promote antitumor immunity in melanoma 20 samples shares antitumor, immunity
- GSE263625 Microglial reprogramming enhances antitumor immunity and immunotherapy response in melanoma brain metastases 19 samples shares antitumor, immunity
- GSE299133 Host MTDH orchestrates liver lipid metabolism and CD8+ T cells to suppress antitumor immunity [Hepatocytes] 18 samples shares antitumor, immunity
- GSE243939 Scribble loss promotes pancreatic cancer development through intrinsic and extrinsic mechanisms 15 samples shares pancreatic, loss
- GSE283198 Combined Flt3L and CD40 agonism restores dendritic cell driven T cell immunity in mouse models and patients with pancreatic cancer [mouse] 13 samples shares pancreatic, immunity
- GSE326246 Citraconate preserves T cell stemness and antitumor immunity 9 samples shares antitumor, immunity
- GSE272424 Rejuvenating endogenous antitumor immunity via a chimeric receptor-engineered oncolytic virus targeting tumor-associated macrophages 6 samples shares antitumor, immunity
- GSE309228 Radiation induced YTHDF2 in dendritic cells impairs antitumor immunity 45 samples shares antitumor, immunity
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.