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Epithelial-Immune Metabolic Codependency Fuels Inflammatory Disease [Spatial Transcriptomics]

GSE237771 Homo sapiens Expression profiling by high throughput sequencing; Other 4 samples Submitted 2024/04/01 Platform GPL24676
Summary
Inflammatory skin diseases are spurred by unchecked immune-epithelial circuits. However, the specific metabolic factors involved in crosstalk and their impact on the dysregulation of these two cellular components are not well understood. To better decipher the metabolic factors involved in psoriasis, we employed spatial transcriptomics (ST), a ground-breaking technology that precisely maps gene expression from histologically-intact tissue sections. These findings identify therapeutically targetable metabolic vulnerabilities in inflammatory skin disease by unveiling a remarkable coordination of metabolic processes between the epithelial and immune compartments.
Published in
Metabolic coordination between skin epithelium and type 17 immunity sustains chronic skin inflammation
Subudhi I, Konieczny P, Prystupa A et al. · Immunity 2024 · PMID 38772365 · doi:10.1016/j.immuni.2024.04.022
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Also filed as BioProject PRJNA996584 and SRA study SRP450382. Searching any of these in the dataset finder brings you back here.

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