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Transcriptomic analysis of cell-of-origin CNS neuroblastoma, FOXR2 activated [Multiome]

GSE238050 Mus musculus Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2024/10/07 Platform GPL24247
Summary
The transcription factor FOXR2 is the universal driver of childhood central nervous system neuroblastoma, FOXR2 activated (NB-FOXR2). NB-FOXR2 tumors arise exclusively in the brain hemispheres, and despite morphological similarities to other pediatric brain tumors, they are a molecularly distinct entity based on DNA methylation profiling. The cell-of-origin is unknown. Here, we profiled a cohort of rare NB-FOXR2 tumors by bulk and single-cell transcriptomics. Through systematic comparative analyses, we delineate tumor transcriptional states and candidate cell-of-origin. More broadly, we demonstrate systematic molecular profiling of childhood cancers to orient oncogenic targeting for in vivo modeling, a critical resource for the study of rare tumors and development of therapeutics.
Published in
FOXR2 Targets LHX6+/DLX+ Neural Lineages to Drive Central Nervous System Neuroblastoma
Jessa S, De Cola A, Chandarana B et al. · Cancer research 2025 · PMID 39495206 · doi:10.1158/0008-5472.CAN-24-2248
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Direct links to NCBI, no account and no request form: the whole study as GSE238050_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA997825 and SRA study SRP451016. Searching any of these in the dataset finder brings you back here.

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