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Phenotype and function of ex vivo expanded liver progenitor-like cells through biliary epithelial cells reversion

GSE238160 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/07/24 Platform GPL21103Platform GPL21273
Summary
The current study combined genetic lineage tracing with in vitro small-molecule-based reprogramming to define liver progenitor cells (LPCs) derived from hepatic parenchymal and non-parenchymal cells (NPCs). tdTom+ hepatocytes were isolated from ROSA26tdTomato mice following AAV8-Tbg-Cre-mediated recombination, ALB/GFP-EpCAM- NPCs were isolated from AlbCreERT/R26GFP mice and EpCAM+ biliary epithelial cells (BECs) from wild-type intrahepatic bile ducts. A cocktail of small molecules was used to convert the isolated cells into LPCs.
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Also filed as BioProject PRJNA998064 and SRA study SRP451206. Searching any of these in the dataset finder brings you back here.

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