Loss of PPARα function promotes epigenetic dysregulation of lipid homeostasis driving ferroptosis and pyroptosis lipotoxicity in Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) [RNA-seq]
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 4 × WT_CHOW vs 3 × WT_CDAHFD vs 3 × KO_CDAHFD vs 2 × KO_CHWGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Loss of PPARα function promotes epigenetic dysregulation of lipid homeostasis driving ferroptosis and pyroptosis lipotoxicity in metabolic dysfunction associated Steatotic liver disease (MASLD)Frontiers in molecular medicine · 2023
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE238201_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA998364 and SRA study SRP451339. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7660271 WT_CHOW_1 WT_CHOW
- GSM7660272 WT_CHOW_2 WT_CHOW
- GSM7660273 WT_CHOW_3 WT_CHOW
- GSM7660274 WT_CHOW_4 WT_CHOW
- GSM7660275 WT_CDAHFD_1 WT_CDAHFD
- GSM7660276 WT_CDAHFD_2 WT_CDAHFD
- GSM7660277 WT_CDAHFD_3 WT_CDAHFD
- GSM7660278 KO_CHW_1 KO_CHW
- GSM7660279 KO_CHW_2 KO_CHW
- GSM7660280 KO_CDAHFD_1 KO_CDAHFD
- GSM7660281 KO_CDAHFD_2 KO_CDAHFD
- GSM7660282 KO_CDAHFD_3 KO_CDAHFD
- GSE328680 Hepatocyte-specific PPARγ Deletion Uncovers Role of an Antagonistic PPARγ–HNF4α Transcriptional Axis in MASLD Progression 12 samples shares masld, ppar
- GSE304630 Integrated Transcriptomic and Functional Dissection of Reversible Liver-Heart Dysfunction in a Preclinical MASLD-HFpEF Model 18 samples shares masld, dysfunction
- GSE291363 Mitochondrial dysfunction charachterizes the multigenerational effects of maternal obesity on MASLD 18 samples shares masld, dysfunction
- GSE332777 miR-155-driven dysregulation of the PPARγ/PGC-1α/ERRα-Drp1 axis contributes to mitochondrial damage in hypoxic/ischemic neuronal cells 12 samples shares ppar, dysregulation
- GSE287727 Dysregulation of bile acid metabolism exacerbates diet-induced MASLD development in HuR deficient male mouse livers. 12 samples shares masld, dysregulation
- GSE225317 Trophectoderm biopsies of blastocysts for preimplantation genetic testing following in vitro fertilization and embryo culture increases epigenetic dysregulation in a mouse model [RNA-seq] 110 samples shares dysregulation, epigenetic
- GSE279885 Perimenopausal State Oestradiol to Progesterone Imbalance Drives Alzheimer’s Risk via ERRα Dysregulation and Energy Dyshomeostasis 59 samples shares dysregulation, homeostasis
- GSE319246 ApoE4 Drives Microglial Lipid Dysregulation in Alzheimer’s Disease via Epigenetic Reprogramming of the AsxL1/LXRα–H3K4me3 Axis 24 samples shares dysregulation, epigenetic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.