Mitochondrial dysfunction charachterizes the multigenerational effects of maternal obesity on MASLD
RNA-seq (gene expression) · mouse · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 5 × Liver, NC/NC, vs 5 × Liver, NC/WD, vs 5 × Liver, Multigenerational WD without fibrosis, vs 3 × Liver, Multigenerational WD with fibrosis,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Mitochondrial dysfunction characterises the multigenerational effects of maternal obesity on MASLDJHEP reports : innovation in hepatology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE291363_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1233242 and SRA study SRP568677. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 4 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8833905 Liver, NC/NC, rep1 Liver, NC/NC,
- GSM8833906 Liver, NC/NC, rep2 Liver, NC/NC,
- GSM8833907 Liver, NC/WD, rep1 Liver, NC/WD,
- GSM8833908 Liver, NC/NC, rep3 Liver, NC/NC,
- GSM8833909 Liver, NC/NC, rep4 Liver, NC/NC,
- GSM8833910 Liver, NC/WD, rep2 Liver, NC/WD,
- GSM8833911 Liver, NC/WD, rep3 Liver, NC/WD,
- GSM8833912 Liver, NC/WD, rep4 Liver, NC/WD,
- GSM8833913 Liver, Multigenerational WD without fibrosis, rep1 Liver, Multigenerationa…
- GSM8833914 Liver, Multigenerational WD with fibrosis, rep1 Liver, Multigenerationa…
- GSM8833915 Liver, Multigenerational WD without fibrosis, rep2 Liver, Multigenerationa…
- GSM8833916 Liver, Multigenerational WD without fibrosis, rep3 Liver, Multigenerationa…
- GSM8833917 Liver, Multigenerational WD with fibrosis, rep2 Liver, Multigenerationa…
- GSM8833918 Liver, Multigenerational WD without fibrosis, rep4 Liver, Multigenerationa…
- GSM8833919 Liver, Multigenerational WD with fibrosis, rep3 Liver, Multigenerationa…
- GSM8833920 Liver, Multigenerational WD without fibrosis, rep5 Liver, Multigenerationa…
- GSM8833921 Liver, NC/NC, rep5 Liver, NC/NC,
- GSM8833922 Liver, NC/WD, rep5 Liver, NC/WD,
- GSE293219 Adipocyte-specific Mlkl knockout mitigates obesity-induced metabolic dysfunction by enhancing mitochondrial functions. 36 samples shares mitochondrial, dysfunction, obesity
- GSE316731 Endothelial Cell-specific Activation of NOX1 Drives Obesity and Metabolic Syndrome via Skeletal Muscle Mitochondrial Dysfunction with Novel Genetic Signatures 12 samples shares mitochondrial, dysfunction, obesity
- GSE304630 Integrated Transcriptomic and Functional Dissection of Reversible Liver-Heart Dysfunction in a Preclinical MASLD-HFpEF Model 18 samples shares masld, dysfunction
- GSE238201 Loss of PPARα function promotes epigenetic dysregulation of lipid homeostasis driving ferroptosis and pyroptosis lipotoxicity in Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) [RNA-seq] 12 samples shares masld, dysfunction
- GSE280991 Partial restoration of the mitochondrial dysfunction by AAV-Ant1 (Slc25a4) transduction protects against dilated cardiomyopathy in Slc25a4-/- plus mtDNA mutant mice 115 samples shares mitochondrial, dysfunction
- GSE280273 A multi-omics census reveals miRNA miR-let-7 as instigator of paternal mitochondrial dysfunction and in epigenetic heredity of intergenerational metabolic decline [F0_Liv_eWAT_RNAseq] 36 samples shares mitochondrial, dysfunction
- GSE300519 Neurotoxicity, α-Synuclein Pathology, and Mitochondrial Dysfunction: A Comparative Study of Three Parkinson’s Disease Mouse Models 35 samples shares mitochondrial, dysfunction
- GSE291086 Neuronal ABCA7 deficiency aggravates mitochondrial dysfunction and neurodegeneration in Alzheimer’s disease 24 samples shares mitochondrial, dysfunction
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.