The tumor intrinsic role of the m6A reader YTHDF2 in regulating immune evasion [RNA-seq]
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The tumor-intrinsic role of the m(6)A reader YTHDF2 in regulating immune evasionScience immunology · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE239423_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA999254 and SRA study SRP451815. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 6 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7664727 MC38_gNC_MeRIP_1 MC38_gNC_MeRIP
- GSM7664728 MC38_gNC_MeRIP_2 MC38_gNC_MeRIP
- GSM7664729 MC38_gNC_MeRIP_3 MC38_gNC_MeRIP
- GSM7664730 MC38_gY2_MeRIP_1 MC38_gY2_MeRIP
- GSM7664731 MC38_gY2_MeRIP_2 MC38_gY2_MeRIP
- GSM7664732 MC38_gY2_MeRIP_3 MC38_gY2_MeRIP
- GSM7664733 MC38_gNC_Input_1 MC38_gNC_Input
- GSM7664734 MC38_gNC_Input_2 MC38_gNC_Input
- GSM7664735 MC38_gNC_Input_3 MC38_gNC_Input
- GSM7664736 MC38_gY2_Input_1 MC38_gY2_Input
- GSM7664737 MC38_gY2_Input_2 MC38_gY2_Input
- GSM7664738 MC38_gY2_Input_3 MC38_gY2_Input
- GSM7664739 MC38-RIP-input--1 MC38-RIP-input
- GSM7664740 MC38-RIP-input--2 MC38-RIP-input
- GSM7664741 MC38-RIP--1 MC38-RIP
- GSM7664742 MC38-RIP--2 MC38-RIP
- GSE283694 Bacterial immunotherapy leveraging IL-10R hysteresis for both phagocytosis evasion and tumor immunity revitalization [RNA-seq] 21 samples shares evasion, rna-seq
- GSE290839 PD-1 regulates tumor-infiltrating CD8+ T cells in both a cell-intrinsic and cell-extrinsic fashion [scRNA-seq] 20 samples shares intrinsic, rna-seq
- GSE228456 Cell-intrinsic effect of IL-7R signaling of monocytes within C57BL/6J mouse ears infected with Leishmania major [bulk RNA-seq] 87 samples shares intrinsic, rna-seq
- GSE301299 Multi-omics analysis identifies intrinsic Trp53 driven metastatic breast cancer subtypes [RNA-seq] 51 samples shares intrinsic, rna-seq
- GSE325918 Nuclear receptor Nur77 resolves the inflammatory response of macrophages primarily by regulating expression of AP-1 transcription factors and their target genes [RNA-seq] 32 samples shares regulating, rna-seq
- GSE296482 A cell-intrinsic glucocorticoid biosynthesis and sensing circuit maintains homeostatic Th17 cell state [RNA-seq] 31 samples shares intrinsic, rna-seq
- GSE269318 Cancer-intrinsic Cxcl5 orchestrates global metabolic reprogramming of three dimensional cancers by upregulating Hif1α and Myc expression 31 samples shares regulating, intrinsic
- GSE335221 Effect of keratinocyte-intrinsic VISTA deletion on UV-induced type I interferon and inflammatory gene expression in mouse epidermis [bulk RNA-seq] 28 samples shares intrinsic, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.