Condensate-promoting ENL mutation induces tumorigenesis via chromatin remodeling
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 74 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 74 samples: 61 distinct titles, 13 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Condensate-Promoting ENL Mutation Drives Tumorigenesis In Vivo Through Dynamic Regulation of Histone Modifications and Gene ExpressionCancer discovery · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE239470_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA999344 and SRA study SRP451846. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 74 sample titles: 61 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7665650 LSK cells, Enl-WT, H3K27ac, CUT&Tag
- GSM7665651 LSK cells, Enl-T1, H3K27ac, CUT&Tag
- GSM7665652 GMP cells, Enl-WT, H3K27ac, CUT&Tag
- GSM7665653 GMP cells, Enl-T1, H3K27ac, CUT&Tag
- GSM7665654 L-GMP cells, Enl-WT, H3K27ac, CUT&Tag
- GSM7665655 L-GMP cells, Enl-T1, H3K27ac, CUT&Tag
- GSM7665656 cKit+Mac1+ cells, Enl-WT, H3K27ac, CUT&Tag
- GSM7665657 cKit+Mac1+ cells, Enl-T1, H3K27ac, CUT&Tag
- GSM7665658 cKit-Mac1+ cells, Enl-WT, H3K27ac, CUT&Tag
- GSM7665659 cKit-Mac1+ cells, Enl-T1, H3K27ac, CUT&Tag
- GSM7665660 LSK cells, Enl-WT, H3K27me3, CUT&Tag
- GSM7665661 LSK cells, Enl-T1, H3K27me3, CUT&Tag
- GSM7665662 GMP cells, Enl-WT, H3K27me3, CUT&Tag
- GSM7665663 GMP cells, Enl-T1, H3K27me3, CUT&Tag
- GSM7665664 L-GMP cells, Enl-WT, H3K27me3, CUT&Tag
- GSM7665665 L-GMP cells, Enl-T1, H3K27me3, CUT&Tag
- GSM7665666 cKit+Mac1+ cells, Enl-WT, H3K27me3, CUT&Tag
- GSM7665667 cKit+Mac1+ cells, Enl-T1, H3K27me3, CUT&Tag
- GSM7665668 cKit-Mac1+ cells, Enl-WT, H3K27me3, CUT&Tag
- GSM7665669 cKit-Mac1+ cells, Enl-T1, H3K27me3, CUT&Tag
- GSM7665670 LSK cells, Enl-T1, H3K27ac, TDI11055, CUT&Tag
- GSM7665671 GMP cells, Enl-T1, H3K27ac, TDI11055, CUT&Tag
- GSM7665672 GMP cells, Enl-WT, p300, ChIP-seq
- GSM7665673 GMP cells, Enl-T1, p300, ChIP-seq
- GSM7665674 L-GMP cells, Enl-WT, p300, ChIP-seq
- GSM7665675 L-GMP cells, Enl-T1, p300, ChIP-seq
- GSM7665676 GMP cells, Enl-WT, input, ChIP-seq
- GSM7665677 LSK cells, Enl-WT, Rep1
- GSM7665678 LSK cells, Enl-WT, Rep2
- GSM7665679 LSK cells, Enl-T1, Rep1
- GSM7665680 LSK cells, Enl-T1, Rep2
- GSM7665681 GMP cells, Enl-WT, Rep1
- GSM7665682 GMP cells, Enl-WT, Rep2
- GSM7665683 GMP cells, Enl-T1, Rep1
- GSM7665684 GMP cells, Enl-T1, Rep2
- GSM7665685 L-GMP cells, Enl-T1, Rep1
- GSM7665686 L-GMP cells, Enl-T1, Rep2
- GSM7665687 cKit+Mac1+ cells, Enl-WT, Rep1
- GSM7665688 cKit+Mac1+ cells, Enl-WT, Rep2
- GSM7665689 cKit+Mac1+ cells, Enl-T1, Rep1
+ 34 more — browse all 74 samples with per-sample file links →
- GSE239469 Condensate-promoting ENL mutation induces tumorigenesis via chromatin remodeling [RNA-seq] 28 samples shares enl, condensate-promoting, tumorigenesis, remodeling, chromatin, mutation, induces
- GSE300757 Efferocytosis induces proangiogenic function and chromatin remodeling in tumor-associated macrophages 127 samples shares remodeling, chromatin, induces
- GSE306916 Efferocytosis induces proangiogenic function and chromatin remodeling in tumor-associated macrophages [ATAC-seq] 12 samples shares remodeling, chromatin, induces
- GSE243608 Dynamic Chromatin Alteration Induces Oncogenic Hijacking by Essential Transcriptional Factors during Medulloblastoma Tumorigenesis [[CUT&Tag 2] 9 samples shares tumorigenesis, chromatin, induces
- GSE283435 Gain-of-function ENL YEATS domain mutations impede nephrogenesis through gene expression control 34 samples shares enl, mutation
- GSE313096 Leukemia aggressiveness is driven by chromatin remodeling and expression changes of core regulators 40 samples shares remodeling, chromatin
- GSE274492 The remodeling of bivalent chromatin is essential for mouse peri-implantation embryogenesis [Valid RNA-Seq] 200 samples shares remodeling, chromatin
- GSE259380 TG6050, an oncolytic vaccinia virus encoding interleukin-12 and anti-CTLA-4 antibody induces tumor regression through profound tumor microenvironment remodeling and strong antitumor adaptive immune response [RNA-seq] 149 samples shares remodeling, induces
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.