Leukemia aggressiveness is driven by chromatin remodeling and expression changes of core regulators
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 40 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 40 samples: 10 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Multiomic analysis of clonal development reveals new regulators of leukemic cell growthGenes & development · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE313096_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1378252 and SRA study SRP540497. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 6 samples read as cases, 11 as controls.
How we read this: 10 replicated groups read from 40 sample titles; they account for 25 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8591372 Aggressive, control, replicate 1 Aggressive, control,
- GSM8591373 Aggressive, control, replicate 2 Aggressive, control,
- GSM8591374 Aggressive, control, replicate 3 Aggressive, control,
- GSM8591375 Aggressive, Irx5 overexpression, replicate 1 Aggressive, Irx5 overex…
- GSM8591376 Aggressive, Irx5 overexpression, replicate 2 Aggressive, Irx5 overex…
- GSM8591377 Aggressive, Irx5 overexpression, replicate 3 Aggressive, Irx5 overex…
- GSM8591378 Aggressive, Plag1 overexpression, replicate 3 Aggressive, Plag1 overe…
- GSM8591379 Aggressive, Plag1 overexpression, replicate 4 Aggressive, Plag1 overe…
- GSM8591380 Aggressive, Plag1 overexpression, replicate 5 Aggressive, Plag1 overe…
- GSM8591381 Early, control, replicate 1 Early, control,
- GSM8591382 Early, control, replicate 2 Early, control,
- GSM8591383 Early, control, replicate 3 Early, control,
- GSM8591384 Early, Smad1, replicate 1 Early, Smad1,
- GSM8591385 Early, Smad1, replicate 2 Early, Smad1,
- GSM8591386 Early, Smad1, replicate 3 Early, Smad1,
- GSM8591387 Aggressive, clone 1, Input
- GSM8591388 Aggressive, clone 1, H3K27ac
- GSM8591389 Aggressive, clone 1, H3K27me3
- GSM8591390 Aggressive, clone 1, H3K4me1 Aggressive, clone 1, H3…
- GSM8591391 Aggressive, clone 1, H3K4me3 Aggressive, clone 1, H3…
- GSM8591392 Aggressive, clone 2, Input
- GSM8591393 Aggressive, clone 2, H3K27ac
- GSM8591394 Aggressive, clone 2, H3K27me3
- GSM8591395 Aggressive, clone 2, H3K4me1 Aggressive, clone 2, H3…
- GSM8591396 Aggressive, clone 2, H3K4me3 Aggressive, clone 2, H3…
- GSM8591397 Early, clone 1, Input
- GSM8591398 Early, clone 1, H3K27ac
- GSM8591399 Early, clone 1, H3K27me3
- GSM8591400 Early, clone 1, H3K4me1 Early, clone 1, H3K4me
- GSM8591401 Early, clone 1, H3K4me3 Early, clone 1, H3K4me
- GSM8591402 Early, clone 2, Input
- GSM8591403 Early, clone 2, H3K27ac
- GSM8591404 Early, clone 2, H3K27me3
- GSM8591405 Early, clone 2, H3K4me1 Early, clone 2, H3K4me
- GSM8591406 Early, clone 2, H3K4me3 Early, clone 2, H3K4me
- GSM8591407 Normal, Input
- GSM8591408 Normal, H3K27ac
- GSM8591409 Normal, H3K27me3
- GSM8591410 Normal, H3K4me1 Normal, H3K4me
- GSM8591411 Normal, H3K4me3 Normal, H3K4me
- GSE239470 Condensate-promoting ENL mutation induces tumorigenesis via chromatin remodeling 74 samples shares remodeling, chromatin
- GSE300757 Efferocytosis induces proangiogenic function and chromatin remodeling in tumor-associated macrophages 127 samples shares remodeling, chromatin
- GSE289108 Neurons undergo IFNγ-driven persistent epigenetic shifts and synaptic remodeling in the inflamed brain [ChIP-Seq] 57 samples shares remodeling, driven
- GSE278100 Foxa1-Mediated Chromatin Remodeling and Enhancer Reprogramming Promotes Gemcitabine Resistance in Pancreatic Cancer 54 samples shares remodeling, chromatin
- GSE299114 Endothelial Cells retain inflammatory memory through chromatin remodeling [RNA-Seq 2] 53 samples shares remodeling, chromatin
- GSE283958 Cohesin recruitment to promoters and enhancers by general transcription factors and chromatin regulators 47 samples shares regulators, chromatin
- GSE301108 Stag2 dependent chromatin remodeling enforces the erythroid-specific Gata1 cistrome 45 samples shares remodeling, chromatin
- GSE274875 A mutant ASXL1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia [Cut & Run] 38 samples shares chromatin, leukemia
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.