Adipocyte lipin 1 is positively associated with human metabolic health and regulates mouse systemic metabolism
RNA-seq (gene expression) · mouse · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 5 × LFD, Liver, Control vs 5 × LFD, Liver, KO vs 5 × HFD, Liver, Control vs 5 × HFD, Liver, KOGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Adipocyte lipin 1 expression associates with human metabolic health and regulates systemic metabolism in miceThe Journal of clinical investigation · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE239490_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA999442 and SRA study SRP451891. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 20 samples.
How we read this: 4 replicated groups read from 24 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7666228 LFD, Liver, Control 1 LFD, Liver, Control
- GSM7666229 LFD, Liver, Control 2 LFD, Liver, Control
- GSM7666230 LFD, Liver, Control 3 LFD, Liver, Control
- GSM7666231 LFD, Liver, Control 4 LFD, Liver, Control
- GSM7666232 LFD, Liver, Control 5 LFD, Liver, Control
- GSM7666233 LFD, Liver, Control 1-5 pooled
- GSM7666234 LFD, Liver, KO 1 LFD, Liver, KO
- GSM7666235 LFD, Liver, KO 2 LFD, Liver, KO
- GSM7666236 LFD, Liver, KO 3 LFD, Liver, KO
- GSM7666237 LFD, Liver, KO 4 LFD, Liver, KO
- GSM7666238 LFD, Liver, KO 5 LFD, Liver, KO
- GSM7666239 LFD, Liver, KO 1-5 pooled
- GSM7666240 HFD, Liver, Control 1 HFD, Liver, Control
- GSM7666241 HFD, Liver, Control 2 HFD, Liver, Control
- GSM7666242 HFD, Liver, Control 3 HFD, Liver, Control
- GSM7666243 HFD, Liver, Control 4 HFD, Liver, Control
- GSM7666244 HFD, Liver, Control 5 HFD, Liver, Control
- GSM7666245 HFD, Liver, Control 1-5 pooled
- GSM7666246 HFD, Liver, KO 1 HFD, Liver, KO
- GSM7666247 HFD, Liver, KO 2 HFD, Liver, KO
- GSM7666248 HFD, Liver, KO 3 HFD, Liver, KO
- GSM7666249 HFD, Liver, KO 4 HFD, Liver, KO
- GSM7666250 HFD, Liver, KO 5 HFD, Liver, KO
- GSM7666251 HFD, Liver, KO 1-5 pooled
- GSE210900 Endogenous p53 Inhibitor TIRR Dissociates Systemic Metabolic Health from Oncogenic Activity - RNAseq data 82 samples shares systemic, health
- GSE329264 Impact of Intestinal Propionate Metabolism on Systemic Metabolic Homeostasis 20 samples shares systemic
- GSE307617 A low protein diet drives short and long-term improvements in metabolic health in a mouse model of sleeve gastrectomy 62 samples shares health
- GSE328946 Sphingosine kinase 2 regulates adipocyte browning and whole-body metabolism 36 samples shares adipocyte
- GSE293219 Adipocyte-specific Mlkl knockout mitigates obesity-induced metabolic dysfunction by enhancing mitochondrial functions. 36 samples shares adipocyte
- GSE286571 Medium-chain triglycerides improve cognition and systemic metabolism in mouse models of Alzheimer's disease 24 samples shares systemic
- GSE297349 CRISPR-Cas9 Screening Reveals Microproteins Regulating Adipocyte Proliferation and Lipid Metabolism [RNA-seq] 18 samples shares adipocyte
- GSE295605 Dermal adipocytes activate hair follicle stem cells through metabolic communication [SDS II] 16 samples shares adipocyte
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.