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RNA-seq of cardiac lineage cells (day 3 of cardiac differentiation) derived from human embryonic stem cells (hESCs) overexpressed with Monkeypox virus-protein revealed the effects of H3L and A29L in human cardiac development.

GSE239712 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/08/28 Platform GPL24676
Summary
Monkeypox virus (MPV) can infect human cells and induces injuries in human. However, whether and how MPV affect the function of human cells remain to be elucidated. Here, we overexpressed H3L and A29L in hESCs, separately. We appliced RNA-seq on cardiac lineage cells (day 3 of cardiac differentiation) derived from human embryonic stem cells (hESCs) overexpressed with Monkeypox virus-proteins (Control, H3L and A29L) and want to know gene expression patterns of control and overexpression cell lines. Subsequent data analyses will help us to know whether and how H3L and A29L affect human cardiac development.
Published in
Monkeypox virus protein H3L induces injuries in human and mouse
Chen S, Huang G, Liu J · Cell death & disease 2024 · PMID 39168969 · doi:10.1038/s41419-024-06990-2
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Also filed as BioProject PRJNA1000609 and SRA study SRP452407. Searching any of these in the dataset finder brings you back here.

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