GEO series
Gene expression profiling in dendritic cell progenitors and dendritic cells
GSE239739
Mus musculus
Expression profiling by high throughput sequencing
47 samples
2024/04/24
GPL19057
Summary
To understand the roles of Irf8 3’ enhancers on Irf8 expression during cDC1 differentiation, we performed RNA-seq analysis of bone marrow cells and splenocytes from wild-type, and the Irf8 enhancer-deficient mice. Phenotypic analysis and integrated analysis of transcriptome data with genome-wide CUT&Tag data analysis for H3K27ac revealed that the +56 kb enhancer acts on other 3′ enhancers via an IRF8-dependent TF program and the +32 kb enhancer acts in cis to activate other 3′ enhancers.
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