eIF4G2-dependent translation of pro-fibrotic mRNAs is essential for cardiac fibroblast activation
RNA-seq (gene expression) · human · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 16 samples: 8 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE239826_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1001020 and SRA study SRP452631. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 8 samples read as cases, 4 as controls.
How we read this: 8 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7674862 Scramble Knockdown total bio rep 1 Scramble Knockdown total
- GSM7674863 Scramble Knockdown total bio rep 2 Scramble Knockdown total
- GSM7674864 eIF4G2 Knockdown total bio rep 1 eIF4G2 Knockdown total
- GSM7674865 eIF4G2 Knockdown total bio rep 2 eIF4G2 Knockdown total
- GSM7674866 Scramble Knockdown polysome bio rep 1 Scramble Knockdown poly…
- GSM7674867 Scramble Knockdown polysome bio rep 2 Scramble Knockdown poly…
- GSM7674868 eIF4G2 Knockdown polysome bio rep 1 eIF4G2 Knockdown polyso…
- GSM7674869 eIF4G2 Knockdown polysome bio rep 2 eIF4G2 Knockdown polyso…
- GSM7674870 control total bio rep 1 control total
- GSM7674871 control total bio rep 2 control total
- GSM7674872 eIF4G2 overexpression total bio rep 1 eIF4G2 overexpression t…
- GSM7674873 eIF4G2 overexpression total bio rep 2 eIF4G2 overexpression t…
- GSM7674874 control bio rep 1 control
- GSM7674875 control bio rep 2 control
- GSM7674876 eIF4G2 overexpression bio rep 1 eIF4G2 overexpression
- GSM7674877 eIF4G2 overexpression bio rep 2 eIF4G2 overexpression
- GSE217494 Targeting Immune-Fibroblast Crosstalk in Myocardial Infarction and Cardiac Fibrosis I 44 samples shares fibroblast, cardiac
- GSE218391 Targeting Immune-Fibroblast Crosstalk in Myocardial Infarction and Cardiac Fibrosis II 21 samples shares fibroblast, cardiac
- GSE285246 Spatially resolved atlas of IPF fibroblastic foci identifies that PAK2 kinase activation is involved in fibrogenesis 12 samples shares fibroblast, activation
- GSE273882 Arginine Promotes The Activation of Human Lung Fibroblasts Independent of Its Metabolism 52 samples shares fibroblast, activation
- GSE267788 Mechanical stretch induces senescence of alveolar epithelial cells and drives fibroblast activation by paracrine mechanisms 25 samples shares fibroblast, activation
- GSE298023 Location and etiology modulate fibroblast activation in the failing human heart 18 samples shares fibroblast, activation
- GSE289881 Exploring fibroblast activation protein as an early biomarker in chronic lung allograft dysfunction 10 samples shares fibroblast, activation
- GSE235244 Senescent cancer-associated fibroblasts in pancreatic adenocarcinoma suppress CD8+ T cell activation and inhibit response to immune checkpoint therapy [hPDAC] 8 samples shares fibroblast, activation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.