Bardoxolone methyl improves nonalcoholic steatohepatitis through inhibition of macrophage recruitment
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 4 × Control Liver, vehicle, vs 4 × NASH Liver, vehicle, vs 4 × NASH Liver, CDDO-Me,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Bardoxolone methyl prevents metabolic dysfunction-associated steatohepatitis by inhibiting macrophage infiltrationBritish journal of pharmacology · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE239861_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1001288 and SRA study SRP452928. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 3 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7675693 Control Liver, vehicle, rep 1 Control Liver, vehicle,
- GSM7675694 Control Liver, vehicle, rep 2 Control Liver, vehicle,
- GSM7675695 Control Liver, vehicle, rep 3 Control Liver, vehicle,
- GSM7675696 Control Liver, vehicle, rep 4 Control Liver, vehicle,
- GSM7675697 NASH Liver, vehicle, rep 1 NASH Liver, vehicle,
- GSM7675698 NASH Liver, vehicle, rep 2 NASH Liver, vehicle,
- GSM7675699 NASH Liver, vehicle, rep 3 NASH Liver, vehicle,
- GSM7675700 NASH Liver, vehicle, rep 4 NASH Liver, vehicle,
- GSM7675701 NASH Liver, CDDO-Me, rep 1 NASH Liver, CDDO-Me,
- GSM7675702 NASH Liver, CDDO-Me, rep 2 NASH Liver, CDDO-Me,
- GSM7675703 NASH Liver, CDDO-Me, rep 3 NASH Liver, CDDO-Me,
- GSM7675704 NASH Liver, CDDO-Me, rep 4 NASH Liver, CDDO-Me,
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- GSE279351 Liver-specific inactivation of Cideb improves metabolic profiles and ameliorates steatohepatitis and fibrosis in animal models for MASH 45 samples shares steatohepatitis, improves
- GSE263273 Increased hepatoprotective effects of the novel farnesoid X receptor agonist INT-787 versus obeticholic acid in a mouse model of nonalcoholic steatohepatitis 28 samples shares steatohepatitis, nonalcoholic
- GSE314637 RNA-seq analysis of macrophage NFATc3 or ASK1 effects on metabolic dysfunction-associated steatohepatitis 28 samples shares steatohepatitis, macrophage
- GSE204856 Immunoregulation of Intrahepatic Bone Marrow Monocyte–Derived Macrophages by Dietary Nitrate Prevents Nonalcoholic Fatty Liver Disease 24 samples shares nonalcoholic, macrophage
- GSE255524 Remote limb ischemic conditioning alleviates nonalcoholic steatohepatitis via extracellular vesicle-mediated muscle-liver crosstalk [RIC Sham] 19 samples shares steatohepatitis, nonalcoholic
- GSE218075 Membrane phospholipid remodeling modulates nonalcoholic steatohepatitis progression by regulating mitochondrial homeostasis. 18 samples shares steatohepatitis, nonalcoholic
- GSE274949 Role of the FOXM1/CMA/ER stress axis in regulating the progression of nonalcoholic steatohepatitis 14 samples shares steatohepatitis, nonalcoholic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.