Increased hepatoprotective effects of the novel farnesoid X receptor agonist INT-787 versus obeticholic acid in a mouse model of nonalcoholic steatohepatitis
RNA-seq (gene expression) · mouse · 28 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 28 samples: 10 × Liver, Vehicle, vs 9 × Liver, OCA 30 mg/kg, vs 9 × Liver, INT-787 30 mg/kg,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Increased hepatoprotective effects of the novel farnesoid X receptor agonist INT-787 versus obeticholic acid in a mouse model of nonalcoholic steatohepatitisPloS one · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE263273_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1096425 and SRA study SRP499857. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 28 samples.
How we read this: 3 replicated groups read from 28 sample titles; they account for 28 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8188951 Liver, Vehicle, Rep 1 Liver, Vehicle,
- GSM8188952 Liver, OCA 30 mg/kg, Rep 1 Liver, OCA 30 mg/kg,
- GSM8188953 Liver, INT-787 30 mg/kg, Rep 1 Liver, INT-787 30 mg/kg,
- GSM8188954 Liver, Vehicle, Rep 2 Liver, Vehicle,
- GSM8188955 Liver, OCA 30 mg/kg, Rep 2 Liver, OCA 30 mg/kg,
- GSM8188956 Liver, INT-787 30 mg/kg, Rep 2 Liver, INT-787 30 mg/kg,
- GSM8188957 Liver, Vehicle, Rep 3 Liver, Vehicle,
- GSM8188958 Liver, OCA 30 mg/kg, Rep 3 Liver, OCA 30 mg/kg,
- GSM8188959 Liver, INT-787 30 mg/kg, Rep 3 Liver, INT-787 30 mg/kg,
- GSM8188960 Liver, Vehicle, Rep 4 Liver, Vehicle,
- GSM8188961 Liver, Vehicle, Rep 5 Liver, Vehicle,
- GSM8188962 Liver, OCA 30 mg/kg, Rep 4 Liver, OCA 30 mg/kg,
- GSM8188963 Liver, INT-787 30 mg/kg, Rep 4 Liver, INT-787 30 mg/kg,
- GSM8188964 Liver, Vehicle, Rep 6 Liver, Vehicle,
- GSM8188965 Liver, INT-787 30 mg/kg, Rep 5 Liver, INT-787 30 mg/kg,
- GSM8188966 Liver, Vehicle, Rep 7 Liver, Vehicle,
- GSM8188967 Liver, OCA 30 mg/kg, Rep 5 Liver, OCA 30 mg/kg,
- GSM8188968 Liver, INT-787 30 mg/kg, Rep 6 Liver, INT-787 30 mg/kg,
- GSM8188969 Liver, Vehicle, Rep 8 Liver, Vehicle,
- GSM8188970 Liver, OCA 30 mg/kg, Rep 6 Liver, OCA 30 mg/kg,
- GSM8188971 Liver, INT-787 30 mg/kg, Rep 7 Liver, INT-787 30 mg/kg,
- GSM8188972 Liver, Vehicle, Rep 9 Liver, Vehicle,
- GSM8188973 Liver, OCA 30 mg/kg, Rep 7 Liver, OCA 30 mg/kg,
- GSM8188974 Liver, INT-787 30 mg/kg, Rep 8 Liver, INT-787 30 mg/kg,
- GSM8188975 Liver, Vehicle, Rep 10 Liver, Vehicle,
- GSM8188976 Liver, OCA 30 mg/kg, Rep 8 Liver, OCA 30 mg/kg,
- GSM8188977 Liver, INT-787 30 mg/kg, Rep 9 Liver, INT-787 30 mg/kg,
- GSM8188978 Liver, OCA 30 mg/kg, Rep 9 Liver, OCA 30 mg/kg,
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- GSE274949 Role of the FOXM1/CMA/ER stress axis in regulating the progression of nonalcoholic steatohepatitis 14 samples shares steatohepatitis, nonalcoholic
- GSE239861 Bardoxolone methyl improves nonalcoholic steatohepatitis through inhibition of macrophage recruitment 12 samples shares steatohepatitis, nonalcoholic
- GSE277498 Hepatoprotective effect of cinnabarinic acid in metabolic dysfunction-associated steatohepatitis 12 samples shares hepatoprotective, steatohepatitis
- GSE218073 Membrane phospholipid remodeling modulates nonalcoholic steatohepatitis progression by regulating mitochondrial homeostasis [LKO_NASH] 10 samples shares steatohepatitis, nonalcoholic
- GSE255526 Remote limb ischemic conditioning alleviates nonalcoholic steatohepatitis via extracellular vesicle-mediated muscle-liver crosstalk [miR_181_RNAseq] 10 samples shares steatohepatitis, nonalcoholic
- GSE218074 Membrane phospholipid remodeling modulates nonalcoholic steatohepatitis progression by regulating mitochondrial homeostasis [Lpcat3_OE] 8 samples shares steatohepatitis, nonalcoholic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.