GEO series
Transcriptional profiling of tumor microenvironment in B2M KO CD40-treated B16 tumors implanted in mice
GSE240148
Mus musculus
Expression profiling by high throughput sequencing
16 samples
2026/02/02
GPL19057
Summary
The immune changes induced by loss of antigen presentation by tumor cells, a common mechanism of acquired resistance to immunotherapy, as well as the mechanisms by which CD40 agonist treatment controls the growth of B2m-null tumors, are unknown. We performed single-cell RNA-seq of total tumor-infiltrating immune cells in control and B2m-null tumors treated with isotype control or CD40 agonist antibodies to identify changes in immune cell states due to tumor cell loss of B2m and agonist CD40 treatment.
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Paper (PMID 41676732) ↗
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