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Gene expression profile at single cell level of CD45 positive and CD45 negative cells sorted from MB49 tumor tissues of male and female mice

GSE240189 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/02/24 Platform GPL24247
Summary
Sex disparities is epidemiologically linked to non-reproductive cancer and is particularly prominent in bladder cancer. In the past, great attention has been paid to the effectors of sex chromosome associated genes and hormones, yet how the immune system to influence the sex differences of tumor progression remains unclear. Here, we developed single-cell RNA sequencing (scRNA-seq) data of mouse bladder tumor-infiltrating immune cells and identified a lipocalin-2+ (LCN2+) senescence-like neutrophil (LSLN) subpopulation that exclusively present in the male tumor microenvironment, and importantly predict a poor prognosis for male patients with bladder cancer.
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Direct links to NCBI, no account and no request form: the whole study as GSE240189_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1002778 and SRA study SRP453612. Searching any of these in the dataset finder brings you back here.

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