Derepressing nuclear pyruvate dehydrogenase induces therapeutic cancer cell reprogramming (RNA-seq_1)
RNA-seq (gene expression) · human · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 24 samples: 21 distinct titles, 3 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Derepressing nuclear pyruvate dehydrogenase induces therapeutic cancer cell reprogrammingCell metabolism · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE240351_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1003427 and SRA study SRP454008. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 24 sample titles: 21 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7696623 PDXC-OS052 DMSO-1
- GSM7696624 PDXC-OS052 DMSO-2
- GSM7696631 PDXC-OS052 M+I -1
- GSM7696632 PDXC-OS052 M+I -2
- GSM7696635 HOS DMSO
- GSM7696636 HOS M+I
- GSM7696637 MG-63 DMSO
- GSM7696638 MG-63 M+I
- GSM7696639 Saos-2 DMSO
- GSM7696640 Saos-2 M+I
- GSM7696641 U-2 OS DMSO
- GSM7696642 U-2 OS M+I
- GSM7696643 KOS7 DMSO
- GSM7696644 KOS7 M+I
- GSM7696645 KOS8 DMSO
- GSM7696646 KOS8 M+I
- GSM7696647 Hs 819.T DMSO
- GSM7696648 Hs 819.T M+I
- GSM7696649 SW1353 DMSO
- GSM7696650 SW1533 M+I
- GSM7696651 Rh30 DMSO
- GSM7696652 Rh30 M+I
- GSM8523362 PDXC-OS052 ISX9-1
- GSM8523363 PDXC-OS052 ISX9-2
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- GSE309595 Longitudinal Analysis of Multiple Myeloma: Therapeutic Response and Immune Microenvironment Dynamics in the Context of Tumor Heterogeneity [scRNA-seq] 270 samples shares therapeutic, rna-seq
- GSE294016 A macrophage-predominant, immunosuppressive immune microenvironment and subtype-specific therapeutic vulnerabilities in advanced salivary gland cancer [bulk RNA-seq] 95 samples shares therapeutic, rna-seq
- GSE232076 In vitro reconstitution of epigenetic reprogramming in the human germ line [RNA-Seq] 89 samples shares reprogramming, rna-seq
- GSE293952 Hypoxia shapes both therapeutic response and resistance in metastatic clear cell renal cell carcinoma [bulk RNA-seq] 61 samples shares therapeutic, rna-seq
- GSE335924 RNA-seq Identifies FOS as a Potential Therapeutic Target Activating Neural Stem Cells via miR-21/SOX2 Pathway in Hypertensive Intracerebral Hemorrhage 53 samples shares therapeutic, rna-seq
- GSE324642 Canonical and isomiR products of miR-142 enhance dendritic cell reprogramming [bulk RNA-seq] 53 samples shares reprogramming, rna-seq
- GSE290805 Meningioma microenvironment harbors a rich immune landscape with therapeutic implications (Bulk RNA-seq part) 47 samples shares therapeutic, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.