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Transcriptomic analysis to identify genes associated with hypothalamus vulnerability in aging mice with cognitive decline

GSE240365 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/07/01 Platform GPL21273
Summary
Normal aging process is accompanied by cognitive decline. Studies have shown that the hypothalamus plays an important role in regulating aging and cognition. However, the exact molecular mechanism remains unclear. Therefore, the present study aimed to identify predictors of aging cognitive decline in the hypothalamus. The behavioral experiment was used to identify learning and memory differences between young and old mice. Transcriptome sequencing was performed on the hypothalamus of young and old mice to identify potential genes.Our data provide the related genes ,which may be potential predictors of cognitive function in the elderly population, which will establish an important foundation for us to further explore the molecular mechanism.
Published in
Transcriptomic analysis to identify genes associated with hypothalamus vulnerability in aging mice with cognitive decline
Tian X, Zhao Z, Zhao J et al. · Behavioural brain research 2024 · PMID 38452974 · doi:10.1016/j.bbr.2024.114943
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Also filed as BioProject PRJNA1003440 and SRA study SRP454015. Searching any of these in the dataset finder brings you back here.

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