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Degenerative and regenerative peripheral processes are associated with persistent painful chemotherapy-induced neuropathies in males and females

GSE240708 Mus musculus (mouse) RNA-seq (gene expression) 53 samples Submitted 2024/08/08 Platform GPL17021
At a glance

RNA-seq (gene expression) · mouse · 53 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Mus musculus (mouse)
Samples
53 samples: 16 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Degenerative and regenerative peripheral processes are associated with persistent painful chemotherapy-induced neuropathies in males and femalesScientific reports · 2024
Summary (written by the submitters)
We investigated biological processes associated with persistency of chemotherapy-induced neuropathies in males and females We then performed gene expression profiling analysis using data obtained from RNA-seq of hind paw and dorsal root ganglion (DRG) of males and females at different time points post-chemotherapy (PTX) treatment.
Published in
Degenerative and regenerative peripheral processes are associated with persistent painful chemotherapy-induced neuropathies in males and females
Naratadam GT, Mecklenburg J, Shein SA et al. · Scientific reports 2024 · PMID 39080341 · doi:10.1038/s41598-024-68485-6
This dataset
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE240708_RAW.tar (it can run to tens of gigabytes).

3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1004649 and SRA study SRP454696. Searching any of these in the dataset finder brings you back here.

Study design
16 conditions, mostly in triplicate
DRG bulk RNA-seq 1d post-PTX male, ×4 DRG bulk RNA-seq 16d post-PTX male, ×4 DRG bulk RNA-seq 31d post-PTX male, ×4 Paw skin bulk RNA-seq 1d post-PTX male, ×4 Paw skin bulk RNA-seq 31d post-PTX male, ×4 DRG bulk RNA-seq 1d post-PTX female, ×3 DRG bulk RNA-seq 16d post-PTX female, ×3 DRG bulk RNA-seq 31d post-PTX female, ×3 +8 more

Supports a between-group comparison across 53 samples.

How we read this: 16 replicated groups read from 53 sample titles; they account for 53 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

+ 13 more — browse all 53 samples with per-sample file links →

Datasets on a similar topic

Search all mouse RNA-seq datasets in GEO →

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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.