Leukocyte-intrinsic ER stress responses contribute to chemotherapy-induced peripheral neuropathy.
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 4 × BMDM, cKO, PTX vs 4 × BMDM, cKO, DMSO vs 4 × BMDM, WT, PTX vs 4 × BMDM, WT, DMSOGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Leukocyte-intrinsic ER stress responses contribute to chemotherapy-induced peripheral neuropathyScience translational medicine · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE309119_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1333999 and SRA study SRP626446. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 4 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9261444 BMDM, cKO, PTX 1 BMDM, cKO, PTX
- GSM9261445 BMDM, cKO, DMSO 1 BMDM, cKO, DMSO
- GSM9261446 BMDM, cKO, PTX 2 BMDM, cKO, PTX
- GSM9261447 BMDM, cKO, DMSO 2 BMDM, cKO, DMSO
- GSM9261448 BMDM, cKO, PTX 3 BMDM, cKO, PTX
- GSM9261449 BMDM, cKO, DMSO 3 BMDM, cKO, DMSO
- GSM9261450 BMDM, cKO, PTX 4 BMDM, cKO, PTX
- GSM9261451 BMDM, cKO, DMSO 4 BMDM, cKO, DMSO
- GSM9261452 BMDM, WT, PTX 1 BMDM, WT, PTX
- GSM9261453 BMDM, WT, DMSO 1 BMDM, WT, DMSO
- GSM9261454 BMDM, WT, PTX 2 BMDM, WT, PTX
- GSM9261455 BMDM, WT, DMSO 2 BMDM, WT, DMSO
- GSM9261456 BMDM, WT, PTX 3 BMDM, WT, PTX
- GSM9261457 BMDM, WT, DMSO 3 BMDM, WT, DMSO
- GSM9261458 BMDM, WT, PTX 4 BMDM, WT, PTX
- GSM9261459 BMDM, WT, DMSO 4 BMDM, WT, DMSO
- GSE333360 Distinct neuroinflammatory effects of individual chemotherapeutics shape chemotherapy-induced peripheral neuropathy in a novel mouse model of CVAD combination regimen. 30 samples shares chemotherapy-induced, peripheral, neuropathy
- GSE240708 Degenerative and regenerative peripheral processes are associated with persistent painful chemotherapy-induced neuropathies in males and females 53 samples shares chemotherapy-induced, peripheral
- GSE225224 Transcriptomic analysis of peripheral neuropathy in a high-fat diet-induced mouse model of type 2 diabetes 46 samples shares peripheral, neuropathy
- GSE263679 Integrated stress response associated with dark microglia contributes to neurodegeneration [TRAP-seq] 29 samples shares contribute, stress
- GSE329323 Establishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded ATXN3 [Advil RNA-seq] 18 samples shares peripheral, neuropathy
- GSE320015 Establishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded ATXN3 12 samples shares peripheral, neuropathy
- GSE320100 Multimodal characterization of sensorimotor peripheral neuropathy in a preclinical mouse model of SCA3 12 samples shares peripheral, neuropathy
- GSE313359 Hippocampal estrogen levels, receptor types and epigenetics contribute to sex-specific memory-vulnerabilities to concurrent acute stresses [Cut & Run] 45 samples shares contribute, stress
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.