Hmgb2 improves astrocyte to neuron conversion by increasing the chromatin accessibility of genes associated with neuronal maturation in a proneuronal factor-dependent manner
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 54 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 54 samples: 37 distinct titles, 8 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Hmgb2 improves astrocyte to neuron conversion by increasing the chromatin accessibility of genes associated with neuronal maturation in a proneuronal factor-dependent mannerGenome biology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE240860_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1005580 and SRA study SRP454950. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 54 sample titles: 37 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7709189 EGF_FGF_Control_1
- GSM7709190 EGF_FGF_Control_2
- GSM7709191 EGF_FGF_Control_3
- GSM7709192 EGF_FGF_Neurog2_1
- GSM7709193 EGF_FGF_Neurog2_2
- GSM7709194 EGF_FGF_Neurog2_3
- GSM7709195 EGF_FGF_Neurog2_Hmgb2_1
- GSM7709196 EGF_FGF_Neurog2_Hmgb2_2
- GSM7709197 EGF_FGF_Neurog2_Hmgb2_3
- GSM7709198 EGF_FGF_Hmgb2_1
- GSM7709199 EGF_FGF_Hmgb2_2
- GSM7709200 EGF_FGF_Hmgb2_3
- GSM7709201 EGF_FGF_Hmgb2_4
- GSM7709202 FGF_Control_1
- GSM7709203 FGF_Control_2
- GSM7709204 FGF_Control_3
- GSM7709205 FGF_Hmgb2_1
- GSM7709206 FGF_Hmgb2_2
- GSM7709207 FGF_Hmgb2_3
- GSM7709208 FGF_Neurog2_Hmgb2_1
- GSM7709209 FGF_Neurog2_Hmgb2_2
- GSM7709210 FGF_Neurog2_Hmgb2_3
- GSM7709211 FGF_Neurog2_1
- GSM7709212 FGF_Neurog2_2
- GSM7709213 FGF_Neurog2_3
- GSM7710782 EGF_FGF_Control_1 [RNA-Seq]
- GSM7710783 EGF_FGF_Control_2 [RNA-Seq]
- GSM7710784 EGF_FGF_Control_3 [RNA-Seq]
- GSM7710785 EGF_FGF_Control_4 [RNA-Seq]
- GSM7710786 EGF_FGF_Control_5 [RNA-Seq]
- GSM7710787 EGF_FGF_Neurog2_1 [RNA-Seq]
- GSM7710788 EGF_FGF_Neurog2_2 [RNA-Seq]
- GSM7710789 EGF_FGF_Neurog2_3 [RNA-Seq]
- GSM7710790 EGF_FGF_Neurog2_Hmgb2_1 [RNA-Seq]
- GSM7710791 EGF_FGF_Neurog2_Hmgb2_2 [RNA-Seq]
- GSM7710792 EGF_FGF_Neurog2_Hmgb2_3 [RNA-Seq]
- GSM7710793 EGF_FGF_Hmgb2_1 [RNA-Seq]
- GSM7710794 EGF_FGF_Hmgb2_2 [RNA-Seq]
- GSM7710795 EGF_FGF_Hmgb2_3 [RNA-Seq]
- GSM7710796 EGF_FGF_Hmgb2_4 [RNA-Seq]
+ 14 more — browse all 54 samples with per-sample file links →
- GSE240857 Hmgb2 improves astrocyte to neuron conversion by increasing the chromatin accessibility of genes associated with neuronal maturation in a proneuronal factor-dependent manner[RNA-Seq] 29 samples shares hmgb2, factor-dependent, accessibility, proneuronal, conversion, increasing, maturation, astrocyte
- GSE240782 Hmgb2 improves astrocyte to neuron conversion by increasing the chromatin accessibility of genes associated with neuronal maturation in a proneuronal factor-dependent manner [ATAC-Seq] 25 samples shares hmgb2, factor-dependent, accessibility, proneuronal, conversion, increasing, maturation, astrocyte
- GSE227933 Dendritic Cell maturation/migration is architected by chromatin accessibility and a tonic organismal IFNgR1 response gradient which governs immune priming and tolerance 32 samples shares accessibility, maturation
- GSE283483 Novel environment exposure drives temporally defined and region-specific chromatin accessibility and gene expression programs in the hippocampus 160 samples shares accessibility
- GSE278051 KLF13 promotes SLE Pathogenesis by modifying chromatin accessibility of key proinflammatory cytokine genes 70 samples shares accessibility
- GSE309545 Inflammatory signaling differentially changes chromatin accessibility and gene expression of the PD-associated kinase LRRK2 between human and mice [multiome mouse] 64 samples shares accessibility
- GSE246707 Liver-specific matrin-3 knockout regulates hepatic transcriptome and chromatin accessibility in mice 42 samples shares accessibility
- GSE269683 CTCF regulates global chromatin accessibility and transcription during rod photoreceptor development 26 samples shares accessibility
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.