GEO series
Dendritic Cell maturation/migration is architected by chromatin accessibility and a tonic organismal IFNgR1 response gradient which governs immune priming and tolerance
GSE227933
Mus musculus
Genome binding/occupancy profiling by high throughput sequencing
32 samples
2026/03/31
GPL24247
Summary
We found that Interferon gamma receptor 1 (IFNgR1) signaling regulates all aspects of tonic maturation including: tissue egress, migration, maturation, antigen capture and presentation, and subtly balances DC ontogeny. Through ATACseq analysis, we further identified that site-specific maturation is architected by chromatin accessibility and NFkB, suggesting IFNg serves as a local tissue-based maturation cue.
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