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UHRF2 mediates resistance to DNA methylation reprogramming in primordial germ cells [RNAseq_E8.5]

GSE240968 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/08/12 Platform GPL21103
Summary
In mammals, primordial germ cells (PGCs) undergo global erasure of DNA methylation with delayed demethylation of germline genes and selective retention of DNA methylation at young retrotransposons. However, the molecular mechanisms of persistent DNA methylation in PGCs remain unclear. Here we report that resistance to DNA methylation reprogramming in PGCs requires UHRF2, the paralog of the DNMT1 cofactor UHRF1. PGCs from Uhrf2 knock-out mice show loss of retrotransposon DNA methylation, while DNA methylation is unaffected in somatic cells of Uhrf2-/- mice. Furthermore, Uhrf2-deficient PGCs show precocious demethylation of germline genes and overexpress meiotic genes in females.
Published in
UHRF2 mediates resistance to DNA methylation reprogramming in primordial germ cells
Bender A, Morel M, Dumas M et al. · Nature communications 2025 · PMID 40783491 · doi:10.1038/s41467-025-61954-0
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Also filed as BioProject PRJNA1005953 and SRA study SRP455399. Searching any of these in the dataset finder brings you back here.

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