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Genome-wide tongue epithelia transcriptomic profiles from K14-rtTA;TRE-FLBmi-1 (KrTB) and KrTB+Doxycycline (KrTB+DOX).

GSE241153 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/08/16 Platform GPL24247
Summary
We developed a transgenic mouse model (truncated K14-rtTA; TRE/Bmi1, KrTB) containing a doxycycline- (dox) controlled, Tet-responsive element system to selectively overexpress Bmi1 only in the basal epithelial SCs of the tongue. Here, we used this model to assess Bmi1 actions in tongue epithelia. Genome-wide transcriptomics revealed increased levels of transcripts involved in the cellular response to hypoxia in Bmi1-overexpressing (KrTB+DOX) mice.
Published in
The transcription factor BMI1 increases hypoxic signaling in oral cavity epithelia
Baquero J, Tang XH, Ferrotta A et al. · Biochimica et biophysica acta. Molecular basis of disease 2024 · PMID 38599260 · doi:10.1016/j.bbadis.2024.167161
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Also filed as BioProject PRJNA1006655 and SRA study SRP455778. Searching any of these in the dataset finder brings you back here.

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