P300 Regulates Histone Crotonylation and Preimplantation Embryo Development (RNA-Seq)
RNA-seq (gene expression) · mouse · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 20 samples: 10 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- P300 regulates histone crotonylation and preimplantation embryo developmentNature communications · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE241194_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1006716 and SRA study SRP455812. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 20 samples.
How we read this: 10 replicated groups read from 20 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7719158 Control 4-cell rep1 Control 4-cell
- GSM7719159 Control 4-cell rep2 Control 4-cell
- GSM7719160 Control Early-8-cell rep1 Control Early-8-cell
- GSM7719161 Control Early-8-cell rep2 Control Early-8-cell
- GSM7719162 Control Late-8-cell rep1 Control Late-8-cell
- GSM7719163 Control Late-8-cell rep2 Control Late-8-cell
- GSM7719164 P300 siRNA 4-cell rep1 P300 siRNA 4-cell
- GSM7719165 P300 siRNA 4-cell rep2 P300 siRNA 4-cell
- GSM7719166 P300 siRNA Early-8-cell rep1 P300 siRNA Early-8-cell
- GSM7719167 P300 siRNA Early-8-cell rep2 P300 siRNA Early-8-cell
- GSM7719168 P300 siRNA Late-8-cell rep1 P300 siRNA Late-8-cell
- GSM7719169 P300 siRNA Late-8-cell rep2 P300 siRNA Late-8-cell
- GSM7719170 P300 siRNA I1394G Late-8-cell rep1 P300 siRNA I1394G Late-…
- GSM7719171 P300 siRNA I1394G Late-8-cell rep2 P300 siRNA I1394G Late-…
- GSM7719172 P300 siRNA NaCr Late-8-cell rep1 P300 siRNA NaCr Late-8-…
- GSM7719173 P300 siRNA NaCr Late-8-cell rep2 P300 siRNA NaCr Late-8-…
- GSM8154275 Control Late-2-cell rep1 Control Late-2-cell
- GSM8154276 Control Late-2-cell rep2 Control Late-2-cell
- GSM8154277 P300 siRNA Late-2-cell rep1 P300 siRNA Late-2-cell
- GSM8154278 P300 siRNA Late-2-cell rep2 P300 siRNA Late-2-cell
- GSE272793 An atlas of small non-coding RNAs in Human Preimplantation Development (Mouse embryo RNA-seq) 132 samples shares preimplantation, rna-seq, embryo
- GSE262791 LaminB1 DamID, RNA-seq and Genome-wide analysis of replication timing in RIF1 depleted preimplantation mouse embryos 468 samples shares preimplantation, rna-seq, embryo
- GSE288348 Disease-associated astrocyte epigenetic memory promotes CNS pathology [sgEp300, sgACLY astrocytes bulk RNA-Seq dataset] 18 samples shares p300, rna-seq
- GSE309162 P300/CBP inhibition with gilteritinib and venetoclax targets leukemia stem cells in epigenetic mutant AML [RNA-Seq] 12 samples shares p300, rna-seq
- GSE337703 p300/CBP inhibition promotes apoptosis in mouse embryos by impairing H1K75ac-mediated DNA repair from the 4-cell to blastocyst stage 8 samples shares p300, embryo
- GSE290816 Cell autonomous regional differences in oligodendrocyte precursor cell development and response to oncohistone H3.3 K27M [RNA-seq] 142 samples shares histone, rna-seq
- GSE285141 Histone H3.3 ensures cell proliferation and genomic stability during myeloid cell development [RNA-seq] 81 samples shares histone, rna-seq
- GSE263902 The translational landscape of mouse oocytes and preimplantation embryos revealed by high-resolution ribosome profiling 272 samples shares preimplantation, embryo
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.