P300/CBP inhibition with gilteritinib and venetoclax targets leukemia stem cells in epigenetic mutant AML [RNA-Seq]
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × FD AML, Control, vs 3 × FD AML, CCS1477, vs 3 × FT AML, CCS1477, vs 2 × FT AML, Control,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE309162_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1334255 and SRA study SRP627070. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 11 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 11 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9262376 FD AML, Control, 1 FD AML, Control,
- GSM9262377 FD AML, CCS1477, 1 FD AML, CCS1477,
- GSM9262378 FD AML, Control, 2 FD AML, Control,
- GSM9262379 FD AML, CCS1477, 2 FD AML, CCS1477,
- GSM9262380 FD AML, Control, 3 FD AML, Control,
- GSM9262381 FD AML, CCS1477, 3 FD AML, CCS1477,
- GSM9262382 FT AML, Control, 1 FT AML, Control,
- GSM9262383 FT AML, CCS1477, 1 FT AML, CCS1477,
- GSM9262384 FT AML, Control, 2 FT AML, Control,
- GSM9262385 FT AML, CCS1477, 2 FT AML, CCS1477,
- GSM9262386 FT AML,Control, 3
- GSM9262387 FT AML, CCS1477, 3 FT AML, CCS1477,
- GSE309163 P300/CBP inhibition with gilteritinib and venetoclax targets leukemia stem cells in epigenetic mutant AML [ChIP-Seq] 16 samples shares p300, cbp, aml, gilteritinib, inhibition, venetoclax, epigenetic, leukemia
- GSE233095 STAT3 inhibition permits epigenetic reprogramming and TLR9/IRF8-driven differentiation of inv(16) acute myeloid leukemia [RNASEQ_AML_CPGDOX] 12 samples shares aml, inhibition, epigenetic, leukemia
- GSE233096 STAT3 inhibition permits epigenetic reprogramming and TLR9/IRF8-driven differentiation of inv(16) acute myeloid leukemia [RNASEQ_AML_DECSCR] 12 samples shares aml, inhibition, epigenetic, leukemia
- GSE264627 CBP/P300 BRD Inhibition Reduces Neutrophil Accumulation and Activates Antitumor Immunity in TNBC 16 samples shares p300, cbp, inhibition
- GSE337703 p300/CBP inhibition promotes apoptosis in mouse embryos by impairing H1K75ac-mediated DNA repair from the 4-cell to blastocyst stage 8 samples shares p300, cbp, inhibition
- GSE280522 p300/CBP-catalyzed acetylation safeguards minor zygotic genome activation via activating DUX [RNA-Seq] 24 samples shares p300, cbp
- GSE250284 NAT10 promotes cancer metastasis by modulating p300/CBP activity through chromatin-associated tRNA [RNA-seq] 9 samples shares p300, cbp
- GSE242193 Single-cell RNA-sequencing reveals the role of p300/CBP in calcium handing ability of prepubertal RV cardiomyocytes. 2 samples shares p300, cbp
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.