Vascular and perivascular cell profiling reveals the molecular and cellular bases of blood-brain barrier heterogeneity
RNA-seq (gene expression) · mouse · 105 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 105 samples: 27 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Characteristics of blood-brain barrier heterogeneity between brain regions revealed by profiling vascular and perivascular cellsNature neuroscience · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE241206_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1006720 and SRA study SRP290179. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 100 samples.
How we read this: 27 replicated groups read from 105 sample titles; they account for 100 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7719256 ME GFP 1 ME GFP
- GSM7719257 Cortex Desmin 1 Cortex Desmin
- GSM7719258 ME GFP 2 ME GFP
- GSM7719259 ME Desmin 1 ME Desmin
- GSM7719260 Cortex Desmin 2 Cortex Desmin
- GSM7719261 Cotex GFP
- GSM7719262 Cortex Desmin 3 Cortex Desmin
- GSM7719263 ME GFP 3 ME GFP
- GSM7719264 Cortex Desmin 4 Cortex Desmin
- GSM7719265 Cortex Desmin 5 Cortex Desmin
- GSM7719266 ME Desmin 2 ME Desmin
- GSM7719267 ME GFP 4 ME GFP
- GSM7719268 ME Desmin 3 ME Desmin
- GSM7719269 ME GFP 5 ME GFP
- GSM7719270 Cortex Desmin 6 Cortex Desmin
- GSM7719271 ME Desmin 4 ME Desmin
- GSM7719272 ME GFP 6 ME GFP
- GSM7719273 ME GFP 7 ME GFP
- GSM7719274 ME Desmin 5 ME Desmin
- GSM7719275 ME GFP 8 ME GFP
- GSM7719276 ME Desmin 6 ME Desmin
- GSM7719277 ME GFP 9 ME GFP
- GSM7719278 ME Desmin 7 ME Desmin
- GSM7719279 ME GFP 10 ME GFP
- GSM7719280 ME Desmin 8 ME Desmin
- GSM7719281 ME GFP 11 ME GFP
- GSM7719282 ME Desmin 9 ME Desmin
- GSM7719283 ME GFP 12 ME GFP
- GSM7719284 Cortex Desmin 7 Cortex Desmin
- GSM7719285 ME Desmin 10 ME Desmin
- GSM7719286 ME GFP 13 ME GFP
- GSM7719287 ME Desmin 11 ME Desmin
- GSM7719288 ME GFP 14 ME GFP
- GSM7719289 ME Desmin 12 ME Desmin
- GSM7719290 ME GFP 15 ME GFP
- GSM7719291 Cortex Desmin 8 Cortex Desmin
- GSM7719292 ME Desmin 13 ME Desmin
- GSM7719293 ME GFP 16 ME GFP
- GSM7719294 Cortex Desmin 9 Cortex Desmin
- GSM7719295 ME Desmin 14 ME Desmin
+ 65 more — browse all 105 samples with per-sample file links →
- GSE325187 Senescent Endothelial Cells in Cerebral Microcirculation Are Key Drivers of Age-Related Blood-Brain Barrier Disruption, Microvascular Rarefaction, and Neurovascular Coupling Impairment in Mice 20 samples shares blood-brain, vascular, barrier
- GSE287964 A blood-brain barrier-like vascular gate limits immunotherapy efficacy in neuroendocrine cancers 12 samples shares blood-brain, vascular, barrier
- GSE229916 Pericytes and perivascular fibroblasts contribute to central nervous system fibrosis in a region dependent manner 832 samples shares perivascular, vascular
- GSE298799 Deconstructing the Intercellular Interactome in Vascular Dementia with Focal Ischemia for Therapeutic Applications 77 samples shares vascular, cellular
- GSE194224 Perivascular adipose tissue plasticity in response to angiotensin II 40 samples shares perivascular, vascular
- GSE248272 Therapeutically targeting perivascular macrophage effector function improves CD8+ T-cell infiltration and response to chemotherapeutic drugs in cancer 30 samples shares perivascular, vascular
- GSE199288 Perivascular fibrosis is mediated by a KLF10-IL-9 signaling axis in CD4+ T cells 27 samples shares perivascular, vascular
- GSE245013 Neutralization of truncated procalcitonin by antibody treatment protects vascular barrier integrity during systemic inflammation 20 samples shares vascular, barrier
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.