Neutralization of truncated procalcitonin by antibody treatment protects vascular barrier integrity during systemic inflammation
RNA-seq (gene expression) · mouse · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 20 samples: 20 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Endothelial cell responses in sepsis are attenuated by targeting truncated procalcitoninNature communications · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE245013_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1026617 and SRA study SRP465481. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 20 sample titles: 20 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7834686 CLP_IgG_ctrl_15_06
- GSM7834687 CLP_IgG_ctrl_16_07
- GSM7834688 CLP_IgG_ctrl_17_08
- GSM7834689 CLP_IgG_ctrl_25_16
- GSM7834690 CLP_IgG_ctrl_26_17
- GSM7834691 CLP_PCT_AB_10_01
- GSM7834692 CLP_PCT_AB_11_02
- GSM7834693 CLP_PCT_AB_12_03
- GSM7834694 CLP_PCT_AB_20_11
- GSM7834695 CLP_PCT_AB_21_12
- GSM7834696 Sham_IgG_ctrl_18_09
- GSM7834697 Sham_IgG_ctrl_19_10
- GSM7834698 Sham_IgG_ctrl_27_18
- GSM7834699 Sham_IgG_ctrl_28_19
- GSM7834700 Sham_IgG_ctrl_29_20
- GSM7834701 Sham_PCT_AB_13_04
- GSM7834702 Sham_PCT_AB_14_05
- GSM7834703 Sham_PCT_AB_22_13
- GSM7834704 Sham_PCT_AB_23_14
- GSM7834705 Sham_PCT_AB_24_15
- GSE318897 L-DOPA treatment promotes sustained neurovascular and synaptic homeostasis in the diabetic retina 53 samples shares treatment, vascular
- GSE299691 Sex-dependent amelioration of laser-induced choroidal neovascularization by Short-Chain Fatty Acid treatment in a mouse model 43 samples shares treatment, vascular
- GSE275350 Effect of anti-CD3 antibody treatment on islet transcriptomes in the nonobese diabetic (NOD) mouse model 12 samples shares treatment, antibody
- GSE249630 Modeling T cell temporal response to cancer immunotherapy rationalize development of combinatorial treatments protocols 1372 samples shares treatment
- GSE332646 Bulk RNA-seq of juvenile mouse liver following NDMA or saline treatment in WT and Mgmt-/- genotypes across multiple timepoints 214 samples shares treatment
- GSE294630 CDA HFD mice analysed for hepatic gene expression after treatment with semaglutide 97 samples shares treatment
- GSE245728 GLP-1 directed NMDA receptor antagonism for obesity treatment 87 samples shares treatment
- GSE235623 MERTK inhibition for the treatment of tissue fibrosis [RNA-seq] 86 samples shares treatment
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.