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Oncogenic Calreticulin Induces Immune Escape by Stimulating TGF-β Expression and Regulatory T Cell Expansion in the Bone Marrow Microenvironment - scRNAseq

GSE241364 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/05/30 Platform GPL24247
Summary
We established a model for myeloproliferative disease in mice, that is based on primary bone marrow expressing human Thrombopoietin receptor and human mutant Calrdel52. To learn more about cellular and transcriptional rearrangements in the bone marrow we performed single cell RNA sequencing comparing bone marrow cells of empty vector control mice with mice that received MPL-Calrdel52 bone marrow.
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Oncogenic Calreticulin Induces Immune Escape by Stimulating TGFβ Expression and Regulatory T-cell Expansion in the Bone Marrow Microenvironment
Schmidt D, Endres C, Hoefflin R et al. · Cancer research 2024 · PMID 38885318 · doi:10.1158/0008-5472.CAN-23-3553
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Also filed as BioProject PRJNA1007754 and SRA study SRP456203. Searching any of these in the dataset finder brings you back here.

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