Human microglia carrying an early-onset Parkinson’s disease mutation display cell-autonomous disease-relevant phenotypes that may worsen neuronal damage
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 3 × in vitro Control vs 3 × in vitro PD vs 3 × transplanted Control vs 3 × transplanted PDGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The A53T Mutation in α-Synuclein Enhances Proinflammatory Activation in Human Microglia Upon Inflammatory StimulusBiological psychiatry · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE241437_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1008159 and SRA study SRP456462. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7728938 in vitro Control1 in vitro Control
- GSM7728939 in vitro Control2 in vitro Control
- GSM7728940 in vitro Control3 in vitro Control
- GSM7728941 in vitro PD1 in vitro PD
- GSM7728942 in vitro PD2 in vitro PD
- GSM7728943 in vitro PD3 in vitro PD
- GSM7728944 transplanted Control1 transplanted Control
- GSM7728945 transplanted Control2 transplanted Control
- GSM7728946 transplanted Control3 transplanted Control
- GSM7728947 transplanted PD1 transplanted PD
- GSM7728948 transplanted PD2 transplanted PD
- GSM7728949 transplanted PD3 transplanted PD
- GSE282665 Human VCP mutant ALS/FTD microglia display immune and lysosomal phenotypes independently of GPNMB 93 samples shares phenotypes, microglia
- GSE287297 Fusion oncoproteins and cooperating mutations define disease phenotypes in NUP98-rearranged leukemia [RNA-seq] 70 samples shares phenotypes, mutation
- GSE310672 Progesterone receptors drive advanced breast cancer phenotypes including circulating tumor- and stem-like cell expansion in the context of ESR1 mutation [RNA-seq] 48 samples shares phenotypes, mutation
- GSE286874 Triglyceride metabolism controls inflammation and microglial phenotypes associated with APOE4 [RNA-seq] 26 samples shares phenotypes, microglia
- GSE245060 Chronic and acute exposure to rotenone lead to distinct Parkinson’s disease-related phenotypes in human iPSC-derived peripheral neurons 15 samples shares phenotypes, parkinson
- GSE302806 Human induced pluripotent stem cell-derived microglia with a CX3CR1-V249I genetic variant exhibit dysfunctional phenotypes and modulate neuronal growth and function 15 samples shares phenotypes, microglia
- GSE287716 Fusion oncoproteins and cooperating mutations define disease phenotypes in NUP98-rearranged leukemia 13 samples shares phenotypes, mutation
- GSE234552 Tracking of donor and recipient immune and leukemia phenotypes after allogeneic stem cell transplantation using mitochondrial DNA mutations. [ASAP-Seq 2] 30 samples shares phenotypes, mutation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.