IL-6 blockade prevents costimulation blockade-resistant allograft rejection by promoting intragraft regulation in T cell-depleted recipients [FFPE]
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 8 × Cardiac allograft, d14, FFPE, control vs 8 × Cardiac allograft, d14, FFPE, aIL6Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- IL-6 inhibition prevents costimulation blockade-resistant allograft rejection in T cell-depleted recipients by promoting intragraft immune regulation in miceNature communications · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE241470_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1008236 and SRA study SRP456504. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 2 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7729537 Cardiac allograft, d14, FFPE, control 1 Cardiac allograft, d14,…
- GSM7729538 Cardiac allograft, d14, FFPE, control 2 Cardiac allograft, d14,…
- GSM7729539 Cardiac allograft, d14, FFPE, control 3 Cardiac allograft, d14,…
- GSM7729540 Cardiac allograft, d14, FFPE, control 4 Cardiac allograft, d14,…
- GSM7729541 Cardiac allograft, d14, FFPE, control 5 Cardiac allograft, d14,…
- GSM7729542 Cardiac allograft, d14, FFPE, control 6 Cardiac allograft, d14,…
- GSM7729543 Cardiac allograft, d14, FFPE, control 7 Cardiac allograft, d14,…
- GSM7729544 Cardiac allograft, d14, FFPE, control 8 Cardiac allograft, d14,…
- GSM7729545 Cardiac allograft, d14, FFPE, aIL6 1 Cardiac allograft, d14,…
- GSM7729546 Cardiac allograft, d14, FFPE, aIL6 2 Cardiac allograft, d14,…
- GSM7729547 Cardiac allograft, d14, FFPE, aIL6 3 Cardiac allograft, d14,…
- GSM7729548 Cardiac allograft, d14, FFPE, aIL6 4 Cardiac allograft, d14,…
- GSM7729549 Cardiac allograft, d14, FFPE, aIL6 5 Cardiac allograft, d14,…
- GSM7729550 Cardiac allograft, d14, FFPE, aIL6 6 Cardiac allograft, d14,…
- GSM7729551 Cardiac allograft, d14, FFPE, aIL6 7 Cardiac allograft, d14,…
- GSM7729552 Cardiac allograft, d14, FFPE, aIL6 8 Cardiac allograft, d14,…
- GSE241472 IL-6 blockade prevents costimulation blockade-resistant allograft rejection by promoting intragraft regulation in T cell-depleted recipients 24 samples shares il-6, blockade-resistant, costimulation, cell-depleted, intragraft, recipients, allograft
- GSE241471 IL-6 blockade prevents costimulation blockade-resistant allograft rejection by promoting intragraft regulation in T cell-depleted recipients [GIL] 8 samples shares il-6, blockade-resistant, costimulation, cell-depleted, intragraft, recipients, allograft
- GSE117677 Influence of low-input RNA from FF and FFPE samples on gene expression quantification by NanoString, microarray and RNA-seq: a comparative study [RNA-seq] 66 samples shares ffpe
- GSE291859 The RNA-binding E3 ligase MKRN2 selectively disrupts IL-6 translation to restrain inflammation [RNA-seq] 18 samples shares il-6
- GSE288947 Spatial transcriptomic and morpho-functional information derived from single mouse FFPE slides allows in-depth fingerprinting of lung fibrosis 13 samples shares ffpe
- GSE263363 Gene expression in Pan02 tumors from mice that were either untreated, treated with a TGFb vaccine, with an anti-IL-6R blocking antibody or the combination of the TGFb vaccine and an anti-IL-6R blocking antibody 13 samples shares il-6
- GSE276001 mRNA Sequencing Analysis of MCM7 Knockdown in Primary Hepatocytes Under IL-6 Stimulation 12 samples shares il-6
- GSE307940 Effect of IL-6 Trans-Signaling Blockade by sgp130 overexpression on hepatic gene expression in the context of mature-onset obesity in mice 12 samples shares il-6
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.