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Single-cell gene expression profiling of SOXC-mutant bone and bone marrow cells

GSE241637 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/03/04 Platform GPL30172
Summary
SOXC genes (i.e., SOX4, SOX11 and SOX12) encode for transcription factors controlling survival, proliferation, commitment and differentiation of several cell types from development onwards. Although human diseases indicate crucial roles for SOXC in bone development and maintenance, SOXC activities in osteoblastic cells remain elusive. Here, we used a mouse model to inactivate SOXC genes in the osteoblast lineage cells using an OsxCre transgene (Sox4fl/fl Sox11fl/fl Sox12fl/fl OsxCre mice referred to as SOXCOsxCre mice) and we used single-cell RNA-sequencing assays to characterize gene expression changes in bone and bone marrow cells in adulthood.
Published in
SOXC are critical regulators of adult bone mass
Angelozzi M, Karvande A, Lefebvre V · Nature communications 2024 · PMID 38580651 · doi:10.1038/s41467-024-47413-2
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Also filed as BioProject PRJNA1009025 and SRA study SRP456930. Searching any of these in the dataset finder brings you back here.

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