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Dynamic analysis of mononuclear transcription profiles of fat in different parts of mice during aging

GSE241718 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/07/17 Platform GPL21273
Summary
Adipose tissue shows significant changes during aging. Here, we used single-nucleus RNA-seq to map the single-nucleus transcription profiles of mouse subcutaneous adipose tissue ( SAT ) and visceral adipose tissue ( VAT ) at a single-nucleus resolution, showing the differences in visceral and subcutaneous adipose tissue changes with aging. The mononuclear sequencing method enabled us to restore all major cell types in mouse white adipose tissue, and we characterized adipocytes, immune cells, and preadipocytes. We demonstrated the existence of different adipocyte subsets and showed that aging leads to a decrease in adipogenic subsets. In addition, with aging, both subcutaneous adipose tissue and visceral adipose tissue showed a decrease in immune mechanisms.
Published in
Dynamics of single-nuclei transcriptomic profiling of adipose tissue from diverse anatomical locations during mouse aging process
Wu Y, Sun Y, Chen L et al. · Scientific reports 2024 · PMID 38997312 · doi:10.1038/s41598-024-66918-w
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Direct links to NCBI, no account and no request form: the whole study as GSE241718_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1009394 and SRA study SRP457075. Searching any of these in the dataset finder brings you back here.

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