hnRNP R promotes O-GlcNAcylation of eIF4G and facilitates axonal protein synthesis
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 4 × WT_soma vs 4 × KO_soma vs 4 × WT_axon vs 4 × KO_axonGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- hnRNP R promotes O-GlcNAcylation of eIF4G and facilitates axonal protein synthesisNature communications · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE242027_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1011234 and SRA study SRP457761. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 4 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7747723 WT_soma_1 WT_soma
- GSM7747724 WT_soma_2 WT_soma
- GSM7747725 WT_soma_3 WT_soma
- GSM7747726 WT_soma_4 WT_soma
- GSM7747727 KO_soma_1 KO_soma
- GSM7747728 KO_soma_2 KO_soma
- GSM7747729 KO_soma_3 KO_soma
- GSM7747730 KO_soma_4 KO_soma
- GSM7747731 WT_axon_1 WT_axon
- GSM7747732 WT_axon_2 WT_axon
- GSM7747733 WT_axon_3 WT_axon
- GSM7747734 WT_axon_4 WT_axon
- GSM7747735 KO_axon_1 KO_axon
- GSM7747736 KO_axon_2 KO_axon
- GSM7747737 KO_axon_3 KO_axon
- GSM7747738 KO_axon_4 KO_axon
- GSE298401 A Transient Increase in Cardiomyocyte Protein O-GlcNAcylation Enhances Susceptibility to Pressure Overload-Induced Cardiac Remodeling 40 samples shares o-glcnacylation, protein
- GSE326587 Microglia coordinate activity-dependent protein synthesis in neurons through metabolic coupling 28 samples shares synthesis, protein
- GSE231357 Syndecan-1 inhibition promotes anti-tumor immune response and facilitates the efficacy of anti-PD1 checkpoint immunotherapy 14 samples shares facilitates, promotes
- GSE231355 Syndecan-1 inhibition promotes anti-tumor immune response and facilitates the efficacy of anti-PD1 checkpoint immunotherapy [kdSdc1_RNAseq] 12 samples shares facilitates, promotes
- GSE254619 Syndecan-1 inhibition promotes anti-tumor immune response and facilitates the efficacy of anti-PD1 checkpoint immunotherapy (kdSdc1 and mutant) 10 samples shares facilitates, promotes
- GSE327618 Targeting microglial phosphatidylethanolamine synthesis pathway promotes GABARAP-associated phagocytosis and A clearance in Alzheimer's disease 9 samples shares synthesis, promotes
- GSE250593 mTORC1 cooperates with tRNA wobble modification to sustain the protein synthesis machinery 46 samples shares synthesis, protein
- GSE294512 eIF4G2-mediated Translation Initiation of Histone Modifiers is Essential for Intestinal Stem Cell Maintenance and Differentiation [RNA-seq] 92 samples shares eif4g
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.