Multi-OMIC analysis of Huntington disease reveals a neuroprotective astrocyte state (snRNA-Seq)
Single-nucleus RNA-seq · human · 65 samples
- What it is
- Single-nucleus RNA-seqGene activity measured in individual nuclei (used when whole cells are hard to isolate, for example from frozen tissue).
- Organism
- Homo sapiens (human)
- Samples
- 65 samples: 34 × OFGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Multi-omic analysis of Huntington's disease reveals a compensatory astrocyte stateNature communications · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE242197_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1011955 and SRA study SRP458079. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 34 samples.
How we read this: 1 replicated groups read from 65 sample titles; they account for 34 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7754778 5575Cin
- GSM7754779 5382Cin
- GSM7754780 5493Cin
- GSM7754781 5404Cin
- GSM7754782 C5700A
- GSM7754783 H5493A
- GSM7754784 C5596A
- GSM7754785 H5575A
- GSM7754786 C5700Cd
- GSM7754787 H5493Cd
- GSM7754788 5596Cd
- GSM7754789 H5575Cd
- GSM7754790 H4161A
- GSM7754791 H5109A
- GSM7754792 C5227A
- GSM7754793 H5263A
- GSM7754794 H5608A
- GSM7754795 H4161Cd
- GSM7754796 C4812Cd
- GSM7754797 H5109Cd
- GSM7754798 C5227Cd
- GSM7754799 H5263Cd
- GSM7754800 H5608Cd
- GSM7754801 H4161Cin
- GSM7754802 H5109Cin
- GSM7754803 C5227Cin
- GSM7754804 H5263Cin
- GSM7754805 H5608Cin
- GSM7754806 C5596Cin
- GSM7754807 C5700Cin
- GSM7754808 H5286Cin
- GSM7754809 OF019 OF
- GSM7754810 OF020 OF
- GSM7754811 OF022 OF
- GSM7754812 OF023 OF
- GSM7754813 OF025 OF
- GSM7754814 OF026 OF
- GSM7754815 OF027 OF
- GSM7754816 OF028 OF
- GSM7754817 OF029 OF
+ 25 more — browse all 65 samples with per-sample file links →
- GSE242195 Multi-OMIC analysis of Huntington disease reveals a neuroprotective astrocyte state (bulk RNA-Seq) 91 samples shares neuroprotective, multi-omic, huntington, astrocyte, state
- GSE285983 Multi-omic characterization of human sural nerves across polyneuropathies [snRNA-seq] 37 samples shares multi-omic, snrna-seq
- GSE288562 Multi-Omics Analysis of the Immunological State at Baseline and Following SARS-CoV-2 mRNA Vaccination in Lung Transplant Recipients 14 samples shares multi-omic, state
- GSE330130 A multi-omics characterization of the human lumbar spinal cord and motor cortex reveals non-overlapping molecular signatures in ALS [snRNA-Seq; snATAC-Seq] 87 samples shares multi-omic, snrna-seq
- GSE282511 Multi-omics analysis in primary T cells elucidates mechanisms behind disease associated genetic loci [RNA-seq] 128 samples shares multi-omic
- GSE289574 Multi-omics Analysis of Skeletal Muscle Identifies Dysregulation of Hypoxia-Induced Genes in Peripheral Artery Disease [RNA-seq] 40 samples shares multi-omic
- GSE268599 Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease 146 samples shares astrocyte
- GSE338964 Computational modeling and preclinical evaluation support targeting somatic instability for Huntington’s disease treatment. 104 samples shares huntington
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.