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RNA Sequencing of Ishikawa Cell Line with NCF2 Knockdown Using Small Interfering RNA

GSE242226 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/06/30 Platform GPL29480
Summary
Progestin therapy is one of the preferred treatment modalities for early-stage endometrial cancer patients wishing to retain fertility and for conservatively managing advanced endometrial cancer. However, a significant number of patients currently do not benefit from progestin therapy due to issues such as progestin resistance. In the past, we established a medroxyprogesterone acetate-resistant Ishikawa cell line. From this, we identified the NCF2 gene, which was highly expressed in the resistant group. Functional validation experiments revealed that knocking down NCF2 can effectively reverse progestin resistance. To explore its mechanism, we performed RNA sequencing post-NCF2 knockdown.
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Also filed as BioProject PRJNA1012309 and SRA study SRP458151. Searching any of these in the dataset finder brings you back here.

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