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Rugulation of TNF-mediated macrophage differentiation and function by RBP-J

GSE242269 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/01/28 Platform GPL17021Platform GPL21103
Summary
RBP-J was initially identified as a key regulator in the canonical Notch signaling pathway. More recent studies have unveiled its important role as a significant player in macrophage polarization, TLR and TNF signaling pathways. Since TNF activates RBP-J, we investigated the transcriptomic changes in murine bone marrow macrophages treated without or with TNF.
Published in
Reciprocal suppression between TGFβ signaling and TNF stimulation finetunes the macrophage inflammatory response
Xia Y, Inoue K, Zheng T et al. · FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 · PMID 38884155 · doi:10.1096/fj.202302230R
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Also filed as BioProject PRJNA1012806 and SRA study SRP458378. Searching any of these in the dataset finder brings you back here.

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